Lancet Gastroen Hepatol: Postoperative celiac irrigation does not improve the survival of patients with stomach cancer

Recurrence of the peritina after surgical removal of stomach cancer is more common, resulting in an increased risk of adverse prognosis in patients.
previous studies have shown that adequate celiac irrigation (EIPL) after surgery can reduce the risk of recurrence of the permission and improve patient survival.
recently examined the effects of EIPL in the treatment of stomach cancer.
This study was open, Phase III, multi-center, randomized, 21-80 years old, cT3 or cT4 gastric cancer patients involved, patients in Korea, China, Japan, Malaysia, Hong Kong and Singapore 22 medical centers for gastric cancer surgery, random eiPL or control.
eipl group after surgery, using 1L of 42 degrees Celsius heat 0.9% physiological saline irrigation, followed by a complete suction of the lotion, repeated 10 times.
end point of the study is total lifetime.
800 patients were involved in the study, including 398 in the EIPL group and 402 in the standard surgical group.
the third interim analysis on August 28, 2019, the study was terminated early because the total lifetime improvement effect of the EIPL group was not significant.
in the 2.4-year follow-up, the total survival period was similar between the groups (HR-1.09), the three-year survival rate of the EIPL group was 77.0%, and the surgical group was 76.7%.
60 adverse events occurred in the EIPL group and 41 in the surgical group.
most common serious adverse events include a matching leak (EIPL vs surgical group, 3% vs 2%), bleeding (2% vs 2%), abdominal abscesses (1% vs 1%), shallow wound infections (2% vs . . . 1%), liver abnormalities (2% vs . 1%), and 10 patients who died from adverse events, including 8 in the EIPL group.
the study, celiac irrigation after surgery can not improve the survival of patients with gastric cancer cure, it is not recommended as a conventional medical means.
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