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Innovation: Xiao Lan, Niu Jianqin and collaborators from the Department of Embryology of Army Military Medical University started from the interaction between oligodendrocytes and astrocytes and found that OPC can promote the development of astrocyte network through paracrine Wnt7b
.
Keywords: oligodendrocytes, paracrine, Wnt7b, astrocyte network Figure 1: The three-dimensional reconstruction model shows the spatial relationship between OPC and astrocytes, the blue is OPC, purple is astrocyte Cells, the warm white dots are Wnt ligands
.
As the global urbanization process continues to accelerate, children suffer from early stress such as lack of care during their growth, and are prone to mental illnesses such as depression and anxiety, and have a higher tendency to suicide
.
The mechanisms of related mental disorders are mostly analyzed from the perspective of neurons, but in recent years, the role of glial cells in the occurrence of diseases has gradually gained attention
.
The Astrocytic network, which is mediated by connexin, coordinates the functions of astrocytes in the region through calcium wave transmission, and through functions such as energy metabolism supply, neurotransmitter and ion homeostasis regulation, etc.
Participate in synaptic transmission and plasticity regulation, and play an important role in the establishment of neural circuits and animal learning and memory behaviors
.
The abnormality of the star glue network has been found in both depression patients and early life stress model animals, but the mechanism is still unclear
.
Advanced Science recently published the research results jointly discovered by Professor Niu Jianqin and Xiao Lan of the Army Military Medical University and researcher Yi Chenju from the Seventh Affiliated Hospital of Sun Yat-sen University "Reduced oligodendrocyte precursor cell impairs astrocytic development in early life stress" (DOI: 10.
1002/advs.
202101181)
.
This thesis uses a variety of conditions to knock out mice, combined with techniques such as behavior, immunofluorescence staining, and fluorescence bleaching recovery, and found that the reduction of oligodendrocyte progenitor cells (OPC) in the early isolation of the mouse brain can inhibit astrocytes The development of plasma cells and astrocyte network affects the activation of neurons
.
Further studies through in vitro experiments, sequencing analysis and in vivo functional loss have found that OPC can release Wnt 7b and regulate the development and network formation of astrocytes in a paracrine form, while the supplementation of exogenous Wnt 7b can effectively alleviate isolation.
The development and network formation of astrocytes in the mouse brain are impeded
.
This paper clarified the mechanism of abnormal mental behavior caused by early stress from the perspective of glial cells, and provided a new theoretical basis for the prevention and treatment of related diseases
.
WILEY paper information: Reduced oligodendrocyte precursor cell impairs astrocytic development in early life stress Yuxin Wang, Yixun Su, Guangdan Yu, Xiaorui Wang, Xiaoying Chen, Bin Yu, Yijun Cheng, Rui Li, Juan C.
Sáez, Chenju Yi, Lan Xiao, Jianqin The above research work of Niu was supported by the National Natural Science Foundation of China (NSFC 31871045, 31970921, 81971309, 31921003)
.
Advanced ScienceDOI: 10.
1002/advs.
202101181 Click "Read the original text" in the lower left corner to view the original text of the paper
.
Introduction to AdvancedScience Journal "Advanced Science" (Advanced Science) Wiley is a high-quality open source journal founded in 2014.
It publishes innovative achievements and cutting-edge progress in various fields such as materials science, physical chemistry, biomedicine, and engineering
.
The journal is dedicated to disseminating scientific research results to the public to the greatest extent, and all articles are freely available
.
The latest impact factor is 15.
840, and the 2020 SCI journals of the Chinese Academy of Sciences are divided into the Q1 area of the material science category and the Q1 area of the engineering technology category
.
Press and hold the QR code on the official WeChat platform of AdvancedScienceNewsWiley's scientific research information.
Follow us to share cutting-edge information｜Focus on scientific research trends to publish scientific research news or apply for information sharing, please contact: ASNChina@Wiley.
com
.
Keywords: oligodendrocytes, paracrine, Wnt7b, astrocyte network Figure 1: The three-dimensional reconstruction model shows the spatial relationship between OPC and astrocytes, the blue is OPC, purple is astrocyte Cells, the warm white dots are Wnt ligands
.
As the global urbanization process continues to accelerate, children suffer from early stress such as lack of care during their growth, and are prone to mental illnesses such as depression and anxiety, and have a higher tendency to suicide
.
The mechanisms of related mental disorders are mostly analyzed from the perspective of neurons, but in recent years, the role of glial cells in the occurrence of diseases has gradually gained attention
.
The Astrocytic network, which is mediated by connexin, coordinates the functions of astrocytes in the region through calcium wave transmission, and through functions such as energy metabolism supply, neurotransmitter and ion homeostasis regulation, etc.
Participate in synaptic transmission and plasticity regulation, and play an important role in the establishment of neural circuits and animal learning and memory behaviors
.
The abnormality of the star glue network has been found in both depression patients and early life stress model animals, but the mechanism is still unclear
.
Advanced Science recently published the research results jointly discovered by Professor Niu Jianqin and Xiao Lan of the Army Military Medical University and researcher Yi Chenju from the Seventh Affiliated Hospital of Sun Yat-sen University "Reduced oligodendrocyte precursor cell impairs astrocytic development in early life stress" (DOI: 10.
1002/advs.
202101181)
.
This thesis uses a variety of conditions to knock out mice, combined with techniques such as behavior, immunofluorescence staining, and fluorescence bleaching recovery, and found that the reduction of oligodendrocyte progenitor cells (OPC) in the early isolation of the mouse brain can inhibit astrocytes The development of plasma cells and astrocyte network affects the activation of neurons
.
Further studies through in vitro experiments, sequencing analysis and in vivo functional loss have found that OPC can release Wnt 7b and regulate the development and network formation of astrocytes in a paracrine form, while the supplementation of exogenous Wnt 7b can effectively alleviate isolation.
The development and network formation of astrocytes in the mouse brain are impeded
.
This paper clarified the mechanism of abnormal mental behavior caused by early stress from the perspective of glial cells, and provided a new theoretical basis for the prevention and treatment of related diseases
.
WILEY paper information: Reduced oligodendrocyte precursor cell impairs astrocytic development in early life stress Yuxin Wang, Yixun Su, Guangdan Yu, Xiaorui Wang, Xiaoying Chen, Bin Yu, Yijun Cheng, Rui Li, Juan C.
Sáez, Chenju Yi, Lan Xiao, Jianqin The above research work of Niu was supported by the National Natural Science Foundation of China (NSFC 31871045, 31970921, 81971309, 31921003)
.
Advanced ScienceDOI: 10.
1002/advs.
202101181 Click "Read the original text" in the lower left corner to view the original text of the paper
.
Introduction to AdvancedScience Journal "Advanced Science" (Advanced Science) Wiley is a high-quality open source journal founded in 2014.
It publishes innovative achievements and cutting-edge progress in various fields such as materials science, physical chemistry, biomedicine, and engineering
.
The journal is dedicated to disseminating scientific research results to the public to the greatest extent, and all articles are freely available
.
The latest impact factor is 15.
840, and the 2020 SCI journals of the Chinese Academy of Sciences are divided into the Q1 area of the material science category and the Q1 area of the engineering technology category
.
Press and hold the QR code on the official WeChat platform of AdvancedScienceNewsWiley's scientific research information.
Follow us to share cutting-edge information｜Focus on scientific research trends to publish scientific research news or apply for information sharing, please contact: ASNChina@Wiley.
com
