Lack of ALA may lead to obesity

The latest research shows that omega-3 deficiency and omega-6 excess can lead to genetic obesity The study, published in the journal fat research, showed that eating an unbalanced Western diet led to an increase in fat mass in mice, which occurs in generations to come In addition to inherited obesity weight, the study also found metabolic disorders, such as insulin deficiency, and the expression of inflammatory genes associated with obesity In general, our data show that continuous intake of high-fat omega-6: Omega-3 will lead to the separation and stable increase of inflammatory stimulants It also increases cellulite The effect of unbalanced intake of unsaturated fatty acids has been confirmed However, when their intake is unbalanced, these important unsaturated fatty acids can lead to obesity and may have long-term effects on human health In the past 40 years, Western sociologists have seen an increase in calorie levels, while omega-6 has increased by 250% and omega-3 intake has decreased by 40% These changes in diet are consistent with a steady increase in hereditary obesity After that, the recommended proportion of omega-6: Omega-3 in Western diet changed from 5:1 to 15:1 (consistent with Europe), while that in the United States was 40:1 α - linolenic acid (ALA) ω - 3 fatty acid is an important fatty acid, which can not be synthesized by human body, so it must be taken from food Sources of ALA include: flaxseed, soybeans, walnuts, and olive oil The intake of ALA recommended by the American Medical Research Institute is 1.6g / day for men and 1.1g / day for women Evaluation of results the study, led by G é rard airhaud of Universit é de Nice Sophia Antipolis in France, showed that several generations of mice ate a Western diet with a high proportion of omega-6: Omega-3, and evaluated the results In order to meet the physiological needs of rats and eat regularly, the food and water of rats were not restricted for successive generations The researchers pointed out that we deliberately chose a casual diet and gave successive generations of male and female mice a Western-style diet The results of genetic study showed that four generations of fat clumps in Western diet increased with the same genetic stability and program The researchers point out that the mice took a Western-style diet and developed a genetic pattern The results show that unbalanced diet can lead to changes in gene expression that control growth and immunity Gene expression analysis of several generations of mouse adipose masses revealed unrelated and problematic changes in some important participating tissues, such as colony stimulating factor (csf3) and antibodies Our data showed that the expression of csf3 increased in successive generations of mice, the researchers noted This result fully shows that csf3 plays an important role in stimulating the growth of adipocyte hematopoietic mother cells The researchers concluded that in a genetically stable animal population, eating food similar to the Western diet is enough to cause the phenomenon of obesity in the next generation Ailhaud and his partners point out that the fat clumps inherited from different generations can increase the expression of csf-3 gene across several generations, and can enhance the reproduction of obesity pioneers But these connections need further study.