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Laboratory-modified HIV virus to study the fitness of HIV-1/HIV-2 chimeras

 Last Update: 2022-09-08
 Source: Internet
 Author: User

Summary

Frequent recombination is a hallmark of retroviral replication

Introduction

Retroviruses package two copies of full-length RNA into viral particles as genomes

For a new retrovirus to be produced by recombination, it must go through several steps

Based on previous observations, the authors hypothesized that most recombinants of distantly related primate lentiviruses have significant replication defects due to impaired interactions between elements from two different parental viruses

In HIV-1 and HIV-2, the packaging of the RNA genome is achieved through the interaction between the structural protein Gag and the RNA packaging signal, which is located in the 5′ untranslated region of HIV-1 and HIV-2 ( UTR) and5' region in unspliced full-length gag RNA

To determine whether chimeric viruses can replicate and adapt, the authors constructed HIV-1-based chimeras containing either the nucleocapsid domain of HIV-2 Gag or the two zinc fingers of HIV-2 nucleocapsid

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