Ka-Miao helps fight the new coronavirus? It needs to be studied

On March 24th Science, a well-known authoritative magazine, reported that research institutions in the Netherlands, britain, Germany and Australia were about to launch a special clinical trial to test whether the century-old anti-tuberculosis vaccine, cajun, can effectively strengthen the body's immune system and help humans fight the new coronary pneumonia epidemic, which is raging around the world.On May 3rd Dr Asahara, of Aichi College University in Japan, also questioned the "anti-epidemic effect" of Mr Ka.So, can the card help in the fight against the new coronavirus? This newspaper has done some combing for the readers.Deep connection: The news that the card may be able to "train" quickly attracted global attention. What is the deep connection between the ancient card seedling and the emerging new coronavirus?The emphasis is on depth because, on the face of it, the two are "wind and cattle are not in the same veil". As a vaccine, the main role is to improve the body's defense against Bacillus tuberculosis, while the new coronavirus is an RNA virus, compared with Bacillus tuberculosis, from structure to genetic material are very different, will not be stimulated by the antibody "mistaken injury."However, in addition to antibodies, a specific immune weapon, the body also has a non-specific immune defenses based on white blood cells.In recent years, researchers in Denmark, the Netherlands and other countries have found that kaka appears to be able to "train immunity", that is, long-term stimulation, training of white blood cells, strengthen the body's non-specific immune system, thereby strengthening the ability to fight other pathogens. In 2018, Mihai Nenetya of Redbod University in Nemegen, the Netherlands, and others written in the journal Cell L that vaccination of card-mediated seedlings can help prevent yellow fever virus infection to some extent.Can it really help fight the new coronavirus that has swept the globe and is so contagious that it's heinous? Researchers around the world can't wait to find out, but what else is there to do besides wait for the results of clinical trials?Paper exchange: the opposite side of the quitesmart scientists think that the world pursues a different policy of vaccination of card-based seedlings, China, Japan and other countries require universal vaccination of newborns, the United States, Italy and other countries are all voluntary, as long as the comparative analysis of different policy countries of the new crown pneumonia epidemic data, perhaps you can see the end.Thus, from the end of March to the end of April, medical preprinted website MedRxiv on the emergence of an air debate, the theme is whether the severity of the outbreak in various countries and card-based vaccination policy is related.On 28 March, Gonzalo Otazu of the New York Polytechnic University and others published an article, Epidemiological Study on the Relationship between Universal Card Vaccination Policy and Reducing Morbidity and Mortality of New Coronary Pneumonia. Statistics show that among middle- and high-income countries, Italy, the United States, Lebanon, the Netherlands and Belgium have never had universal vaccination, with about 264.9 infections per million people with the new coronavirus (264.4 per million infection rates of new crown pneumonia) 9), the number of deaths was about 16.39 (16.39 per million cases of neo-crown pneumonia), while in the other 55 countries where vaccination was widespread, the figures were 59.54 and 0.78, respectively. At the same time, in terms of trends, the earlier universal vaccination is available, the smaller the infection rate of one million. As a result, "the card may provide long-term protection against the current new coronavirus".On April 11th Richard Kellermeier of Baylor College of Medicine and others came up with a different view. Their study found that there is no inevitable link between the million death rate of new crown pneumonia and the time of universal coronary pneumonia, and there is no clear relationship between the daily rate of death of new coronary pneumonia in various countries (i.e., the ratio of the death rate of new crown pneumonia patients to the number of days of outbreak) and whether universal coronary card seedling vaccination is not. On this basis, the article holds that it is impossible to draw clear conclusions based on the available data.On April 15th Mihai Netya, who is leading a clinical trial of the Dutch "Ka-Miao against the New Coronavirus", said that the training of Ka-Kai Miao in the body's immune system "may be an important mechanism to prevent the lethal effects of neo-coronary pneumonia". In order to eliminate the initial detection capacity of the outbreak and other factors, Netya and other specialized studies of the country's new crown pneumonia million infection rate reached a certain "threshold", million death rate over time changes. The results showed that countries that did not have universal vaccination cards grew faster.On April 24th Abigath Srivastaf of the University of South Florida and others published an article, "Is there any evidence that caramelation has a nonse specific protective effect against neo-coronary pneumonia infection, or is there an illusion due to a lack of testing?" , indicating that if differences in detection capabilities are taken into account, the relationship between card-based seedlings and the rate of neo-coronary pneumonia in various countries will cease to exist, and there is no statistical evidence to support the inclusion of card-based seedling vaccination in national immunization plans to have any effect on the infection or death rate of new coronary pneumonia.Asahara Zhengxiong through statistical research found that in the "Diamond Princess" popularized card seedling vaccination countries' nationals and other countries' nationals in the new coronavirus infection rate and mortality rate is not significantly different; National outbreaks may be affected by factors such as national policies to control infectious diseases, changes in human behaviour, genetic differences between groups, and he believes that "the role of vaccination cards may be relatively small". Practical response: Take a more the debate continues, with the two sides on the same level. The World Health Organization and international authoritative journals have taken a more cautious approach than pre-printing the site. On 13 April, WHO noted that there are many "confusing variables" in the current study, including the age structure of the population, the detection rate of new coronaviruses, the stage of development of the outbreak, and there is no evidence that the card-mediated seedling can protect people from the new coronavirus infection, so it is not recommended to prevent the new coronary pneumonia by inoculation card-based seedling. On April 30, The Lancet published a joint article by researchers from the University of Melbourne, WHO, the Icahn School of Medicine at Mount Sinai in the United States, and the University of Bonn in Germany, "Thinking about inoculating card seedlings to mitigate the effects of neocyclic pneumonia", saying that the world needs to follow WHO's recommendations strictly before verifying that card seedlings are effective. "But it would be an important tool for dealing with new coronary pneumonia and future epidemics if the carbasin or another trained immuno-inducer could provide nonse specific protection to bridge the gap before developing a specific vaccine." So, can the card help fight the new coronavirus? I'm afraid we'll have to be patient and wait for clinical trials to come to the fore. (Science and Technology Daily)