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JTO: Study on the prognostic value of KRAS G12C mutation in non-small cell lung cancer (NSCLC): from the European Thoracic Tumor Group's Lung Cancer Database Project

 Last Update: 2021-06-01
 Source: Internet
 Author: User

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Driver gene mutations play an important role in non-small cell lung cancer ( NSCLC ).

Research data showed that 2055 patients underwent KRAS genetic testing, of which 1014 were adenocarcinoma (49%).

Among 2055 patients, KRAS mutation was found in 473 patients (23.

The median follow-up time was 57.

Comparison of each group of os

Among adenocarcinoma patients, the median RFS of patients with Kr_G12C mutation was 46.

Comparison of RFS in each group

Among adenocarcinoma patients , the median time to relapse (TTR) of patients with Kr_G12C mutation was 66.

TTR comparison of each group

In summary, this large study showed that patients with lung adenocarcinoma with KRAS G12C mutations have a poor prognosis.

Original source:

Stephen P Finn, Alfredo Addeo, Urania Dafni, et al.

Stephen P Finn, Alfredo Addeo, Urania Dafni, et al.
Prognostic Impact of KRAS G12C Mutation in Patients With NSCLC: Results From the European Thoracic Oncology Platform Lungscape Project.
J Thorac Oncol.
2021 Jun;16(6):990-1002.
doi: 10.
1016/j.
jtho.
2021.
02.
016.
Epub 2021 Feb 26.

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