"Journal of Hepatology" Pfizer's new crown vaccine latest side effects: or lead to hepatitis cirrhosis liver failure?

Recently, Pfizer just released the data of the second batch of vaccines, which once again caused heated discussions and discussions on the entire Internet

The latest clinical research from Germany found:

COVID-19 mRNA vaccine (BNT162b2) jointly developed by Pfizer and BioNTech may cause rare T cell-mediated autoimmune hepatitis! 

Autoimmune hepatitis is a chronic progressive inflammatory disease of the liver mediated by an autoimmune response

Severe cases can rapidly develop into liver cirrhosis and liver failure

The above research was published in the April 21 issue of the international authoritative journal of liver disease "Journal of Hepatology"

Clinical studies have reported bimodal flares of acute hepatitis following two doses of Pfizer's mRNA vaccine, with flares occurring after both doses

The male patient in the study was 52 years old and had no medical history other than hypothyroidism

The study found that male patients developed jaundice 10 days after the first injection of the mRNA vaccine, and liver function tests (LFT) showed acute mixed hepatocellular/cholestatic hepatitis

On day 25 of vaccination, the patient was hospitalized

Subsequently, 41 days after the first vaccination, the patient received a second dose of the BNT162b2 vaccine

The patient was transferred to a tertiary care center for treatment 26 days after the second vaccination

To find the cause of the patient's hepatitis, the researchers performed serology, polymerase chain reaction (PCR) testing on the patient to rule out hepatitis A, B, C or E, cytomegalovirus (CMV) and Epstein-Barr virus possibility of infection

Autoimmune serology showed mild hyperglobulinemia, borderline positive for antinuclear antibody (ANA), antimitochondrial M2 antibody (AMA-M2), and antismooth muscle antibody, and negative for LKM antibody

The researchers then performed a liver biopsy in the patient and found that the patient's hepatitis had moderate lymphoplasmacytic infiltration with foci of lobular necrosis and apoptosis

The 52-year-old's symptoms were consistent with autoimmune hepatitis, the researchers said

Through the study of various factors, the research team believes that vaccination with BNT162b2 may trigger immune-mediated hepatitis through cellular immune mechanisms

These results suggest that T cells are the key pathogenic immune cell type in this vaccine-associated immune hepatitis, a new subtype of autoimmune hepatitis

(Source: Internet, reference only)