JNNP: Trauma and depressive symptoms in middle-age people with high-risk dementia: Preventive dementia research.

Objective: Alzheimer's disease (AD) and depressive disorder were once thought to be unrelevant.
depression is now thought to be closely related to AD.
depression increases the risk of dementia by 1.65 times in the future, while also increasing the risk of developing from mild cognitive impairment to dementia.
the underlying mechanisms of these two pathology remain uncertain, and the debate continues over whether depression is a risk factor for AD or a pre-existing symptom of the disease itself.
strong evidence that depressive symptoms are a direct result of AD-related brain changes.
Changes in brain structure and function suggest that depression in patients with AD is associated with disruption of the symposia of the forehead and the lower cortical edge pathline, and this study examined the association between childhood trauma, depression, adult cognitive function and dementia risk.
: Participants were recruited through the Dementia Registry Database, the Dementia Joint Research Website, and research information from the Internet and research reports.
study included 378 participants from West London, Oxford and Cambridge.
203 parents were diagnosed with AD, vascular dementia or mixed dementia.
linear and logical models are used to assess the association between childhood trauma, depression, dementia risk, cognitive test scores, and sea mass volume.
Lifelong Trauma Assessment uses a revised life stress checklist, a self-filled questionnaire for 30 projects, to assess the age, risk and subsequent impact of the past year on daily life.
Center for Epidemiology used the Depression Scale (CES-D) to detect high levels of depressive symptoms.
results: 21 out of 54 trauma patients (38.9%) had a CES-D score above 16 or were currently undergoing treatment for depression.
the association between childhood trauma and depressive symptoms was significant (p-0.009).
childhood trauma was associated with depression and reduced body mass, but not with current cognitive function or dementia risk.
21 participants received antidepressants.
to control any possible effects of treatment on brain volume, the authors also analyzed participants who excluded treatment.
results did not change that childhood trauma was associated with a decrease in the size of the sea mass, but poor cognitive performance was due to depression rather than differences in brain structure.
people with a family history of dementia, the prevalence of depression was 25.6%, compared with 23.6% of people without a family history .
11.3 per cent of people with a family history of dementia reported childhood trauma, while only 17.8 per cent of people without a family history of dementia reported it.
: Depression symptoms may be associated with dementia risk in a number of ways, and future studies should consider their subtypes when studying the relationship between depressive symptoms and dementia.
Ritchie K, Carrière I, Gregory S, et al Trauma and depressive symptomatology in middle-aged people at high risk of dementia: THE PREVENT Study Journal of Neurology, Neurosurgery Psython Published Online First: 21 October 2020. doi:10.1136/jnnp-2020-323823MedSci Original Source: MedSci Original Copyright Notice: All notes on this website "Source: Met Medical" or "Source: MedSci Original" text, images and audio and video materials, copyrighted by Mace Medical, not authorized by any media Websites or individuals may not be reproduced, and the authorizing reprints must include "Source: Metz Medicine".
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