JNNP: Tracking the clinical progression of posterior cortical atrophy, implications for diagnosis and post-treatment interventions

Posterior cortical atrophy (PCA) is a neurodegenerative disease primarily associated with the pathology of Alzheimer's disease (AD)
.

In contrast to the main amnestic features of typical AD, the central feature of PCA is visuospatial cognitive impairment

Diagnosis The current study aimed to (1) describe patterns of cognitive decline in PCA over time; and (2) evaluate the potential of a well-validated screening tool to monitor short- and long-term cognitive changes in both clinical and research settings

Eighteen PCA patients (8 women) were from the Oxford Cognitive Impairment Clinic, UK and the Bath Institute for Aged Care, UK
.

Seventeen demographically .
All participants completed the Addenbrooke Cognitive Test Revised (ACE-R) and/or Addenbrooke Cognitive Test III (ACE-III) at two or more time points (M = 4.

statistics

Compared with healthy volunteers, PCA patients had significantly lower scores for all ACE components at baseline (all p<0.

001)

Compared with healthy volunteers, PCA patients had significantly lower scores for all ACE components at baseline (all p<0.

Longitudinal changes in the Addenbrooke Cognitive Test (ACE)

Longitudinal Change in Addenbrooke Cognitive Test (ACE) Longitudinal Change in Addenbrooke Cognitive Test (ACE)

This study assessed patterns of ACE cognitive decline and its role in monitoring PCA clinical progression
.

Differential rate of change for each subdomain of ACE was determined, with the fastest decline observed on the visuospatial component

This study assessed patterns of ACE cognitive decline and its role in monitoring PCA clinical progression

Manage quality of life In addition, given the sensitivity of ACE to PCA, this instrument may provide a reliable endpoint for testing the efficacy of pharmacotherapeutic interventions in clinical trials
.
Taken together, these findings have important implications for both clinical care and future research
.
Furthermore, given the sensitivity of ACE to PCA, the instrument may provide a reliable endpoint for testing the efficacy of pharmacotherapeutic interventions in clinical trials
.
Taken together, these findings have important implications for both clinical care and future research
.
OvermanMJ ,DrummondN ,ButlerCR Overman  MJ Overman Drummond  N Drummond Butler  CR Butler , et al Tracking the clinical progression of posterior cortical atrophy: implications for post-diagnostic and therapeutic interventions Journal of Neurology, Neurosurgery & Psychiatry  Published Online First: 01 February 2022.
  Published Online First: doi:  10.
1136/jnnp-2021-327501 doi:leave a message here