JNNP: The Origin of Seizures of Autoimmune Diseases: A Multi-Center Retrospective Study.

Over the past few decades, autoantibodies have become the root cause of previously unsealable epilepsy and have hinted at a link between autoimmune and epilepsy.
addition to the increased susceptivity to seizures caused by inflammation, many specific autoantibodies also have a direct epileptic effect.
these foundations, the International Anti-Epilepsy Alliance (ILAE) has introduced a new concept of immunological epilepsy in the latest classification, referring to patients with epilepsy who originate directly from epilepsy.
recent report, between 11 and 20.5 percent of epilepsy patients with unknown causes tested positive for specific antibodies.
Methods for outcome symptoms resulting from the constant discovery of autoantibodies associated with epilepsy: We reviewed 92 clinical and clinical data on 92 new forms of epilepsy, epilepsy continuing status or chronic epilepsy patients who were referred to neurology in Verona and Salzburg from January 2014 to July 2019.
In pairs of serum/cerebrospinal fluids (CSFs), fixed and living cell-based assays, tissue-based assays, immune imprinting, and live cell culture in rats to detect anti-glial and anti-glial antibodies.
then calculate the APE2 and RITE2 scores and compare them with clinical and laboratory data.
: autoantibodies (31.5%) were detected in 29/92 patients and multiple positives were observed in 6/29 cases.
ADE2 score (median 5, range 1-15) was significantly associated with antibody-positive rates (p - 0.014), especially for neuropsychiast symptoms (p .lt;01), movement disorders (p . p .lt;0.01), patients with autonotic neurodevelopmental disorders (p . . . 0.03), arm and arm movement disorders (p . 0.03) and a history of cancer (p . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
patients with antibody-negative epilepsy continued to have significantly higher status (p .lt;0.01).
in the RITE2 scoring program, early initiation of immunotherapy was associated with a good treatment response (p s 0.001), while cancer history was significantly more common in non-reactive people (p slt;0.01).
at least 1 year, neuropsychiast symptoms and the continuity of seizures are associated with the maintenance of anti-epileptic drugs.
authors' study has some limitations to consider, including retrospective design, incomplete follow-up, and multi-center approach, which may affect the analysis of clinical data, treatment options, and outcome measurements.
source: MedSci Originals !-- content presentation ends -- !-- to determine whether the login ends.