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JNNP: Survivors of spontaneous intracerebral hemorrhage, the existence of DWI+ lesions is related to recurrent intracerebral hemorrhage

 Last Update: 2021-08-03
 Source: Internet
 Author: User

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Approximately 3 million people worldwide suffer from spontaneous intracerebral hemorrhage (ICH) every year
.

In most patients, ICH is caused by small cerebral vascular disease (SVD), which affects small perforated blood vessels in the brain

Blood vessel

A recent meta-analysis investigating the relationship between DWI+ lesions and various subtypes of ICH showed that the average incidence of DWI+ lesions within 90 days after ICH was 20%
.

In addition, in all ICH, DWI+ lesions are related to previous ICH and other SVD biomarkers on brain MRI

In some studies, poor functional outcomes (assessed by the modified Rankin scale score at 3 months after ICH) were related to the presence of DWI+ lesions, but not related to other studies
.

A study of 97 patients found that during a median follow-up period of 3.

The median follow-up period at 3.

thrombus

They found that: of the 537 participants in RESTART, 247 (median (IQR) age was 75.

7 (69.
6-81.
1) years; 170 men (68.
8%); 120 people started and 127 people avoided antiplatelet therapy ) There were brain MRI sequences at a median 57 days (IQR 19-103) after ICH, and 73 of them (30%) had one or more DWI+ lesions

During a median follow-up of 2 years (1-3), 18 participants had recurrent ICH and 21 participants had ischemic stroke
.

The presence of DWI+ lesions was associated with all strokes (adjusted HR of 2.
2 (95% CI 1.
1 to 4.
2)) and recurrent ICH (4.
8 (95% CI 1.
8 to 13.
2)), but was associated with ischemic stroke (0.

During the median follow-up period of 2 years (1-3), 18 participants had recurrent ICH and 21 participants had ischemic stroke.

The important significance of this study lies in the discovery: The existence of DWI+ lesions in ICH survivors is related to recurrent ICH, but not related to ischemic stroke
.

It has not been found that the existence of DWI+ lesions will change the effect of antiplatelet therapy on recurrent stroke after ICH

The existence of DWI+ lesions in ICH survivors is related to recurrent ICH, but not related to ischemic stroke

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