-
Categories
-
Pharmaceutical Intermediates
-
Active Pharmaceutical Ingredients
-
Food Additives
- Industrial Coatings
- Agrochemicals
- Dyes and Pigments
- Surfactant
- Flavors and Fragrances
- Chemical Reagents
- Catalyst and Auxiliary
- Natural Products
- Inorganic Chemistry
-
Organic Chemistry
-
Biochemical Engineering
- Analytical Chemistry
-
Cosmetic Ingredient
- Water Treatment Chemical
-
Pharmaceutical Intermediates
Promotion
ECHEMI Mall
Wholesale
Weekly Price
Exhibition
News
-
Trade Service
Objective: To study the occurrence and clinical characteristics of sleep disorders in patients with amyotrophic lateral sclerosis (ALS), and to compare the sleep disorders of patients with alS with mutations.
: This study included 204 ALS patients and 206 control groups using case-control studies.
used the Pittsburgh Sleep Quality Index (PSQI) to assess sleep quality.
the Epworth Sleepiness Scale (ESS) to diagnose daytime excessive sleepiness (EDS).
study also looked at other features, including rapid eye movement sleep behavior disorder, resting leg syndrome (RLS), cognitive and psychological disorders.
all ALS patients were sequenced to screen for ALS mutations and divided them into hereditary and non-hereditary subgroups based on genetic test results.
: a total of 114 male and 90 female ALS patients were included, with an average age of 53.5 ±9.9 years.
21 mutations were detected, accounting for 7.4% of familial amyotrophic lateral sclerosis (FALS) and extrinsic amyotrophic lateral sclerosis (SALS).
PQSI and ESS scores for ALS patients were higher than those in the control group (PSQI 6.0 (3.0, 10.0) vs 3.5 (2.0, 5.0) lt;0.01); ess6.0 (3.0, 10.0)vs 4.0 (3.0, 8.0) (p.lt;0.01).
the risk of RLS in alS patients was higher than in the control group (p.lt;0.01).
patients with hereditary ALS were more likely to have EDS (corrected OR 5.2, p.lt;0.01) than non-hereditary ALS patients.
ALPS scored lower on the improved ALS functional scale, with PSQI and ESS scoring higher than non-heritogeneic ALS (p.lt;0.01).
that in the current study, patients with hereditary ALS were more likely to develop sleep-wake disorder than those without hereditary amyotrophic lateral sclerosis.
the former may benefit more from sleep management.
Sun X, Zhao X, Liu Q, et al Study on sleep-wake disorders in patients with genetic and non-genetic amyotrophic lateral sclerosis Journal of Neurology, Neurosurgery and Psypic Published Online First: 21 October 2020. doi: 10.1136/jnnp-2020-324544MedSci Original Source: MedSci Original Copyright Notice: All text, images and audio and video materials on this website that indicate "Source: Met Medical" or "Source: MedSci Original" are owned by Mets Medicine and are not authorized to be reproduced by any media, website or individual. Source: Mays Medicine.
all reprinted articles on this website are for the purpose of transmitting more information and clearly indicate the source and author, and media or individuals who do not wish to be reproduced may contact us and we will delete them immediately.
at the same time reproduced content does not represent the position of this site.
leave a message here
