JNNP: Serum nerve wire light chain predicts long-term prognosis in patients with Green-Bally syndrome

The diagnosis of Green-Barre syndrome (GBS) depends on clinical and electrophysiological indicators and cerebrospinal fluid cytological isolation, but patients vary widely in their performance, clinical course and prognosis.
with the introduction of ultra-sensitive technologies such as single-molecule arrays (SiMoA), the neural wire light chain (NfL) is becoming the most important biomarker of axon damage in neurology, showing elevated levels of NfH in cerebrospinal fluid.
studied serum nerve wire light chain (sNfL) levels as a biological marker for the prognosis of Green-Bally syndrome (GBS).
single-molecule array (SiMoA) was used to measure NfL in the serum (98 cases) and cerebrospinal fluid (CSF) of GBS patients in the Spanish International GBS Results Study (IGOS) and compared it with 53 health control groups (HCs).
the relationship between the sNfL level and the 1-year functional results was analyzed by the authors.
Serum NfL levels were higher than HC (55.49 pg/mL vs 9.83 pg/mL, p-lt;0.0001) and cerebrospinal fluid levels were higher than HC (1308.5 pg/mL vs 440.24 pg/mL, p=0.034).
patients with a history of diarrhoeal diseases were sNfL higher than those with respiratory symptoms or no history of infection (134.90 pg/mL vs 47.86 pg/mL vs 38.02 pg/mL, p=0.016).
sNfL levels were associated with Guillain-Barr's syndrome disability score and the Comprehensive Disability Scale (I-RODS).
sNfL levels were higher in patients with simple motion variants and Miller-Fisher syndrome than in patients with sensory motor GBS (162.18 pg/mL vs. 95.50 pg/mL vs 38.02 pg/mL, p=0.025).
sNfL levels in patients with acute motor axon neuropathy were higher than in other variants (190.55 pg/mL vs 46.79 pg/mL, p=0.013).
sNfL returns to normal levels after 1 year.
critical point for highly specific clinically relevant prognosmations: inability to walk independently, inability to run( sgt;248 pg/mL), and ability to run ( slt; 34 pg/mL).
baseline sNfL levels in GBS patients, the severity of the disease was related to axis mutations, and had independent prognostic value for GBS patients.
-Aguilar L, Camps-Renom P, Lleix?C, et al Serum neurofilament light light chain predicts long-term prognosis in Guillain-Barré syndrome patients Journal of Neurology, Neurosurgery Psython Published Online First: 05 November 2020. doi:10.1136/jnnp-2020-323899MedSci Original Source: MedSci Original Copyright Statement: All notes on this website "Source: Met Medical" or "Source: MedSci Original" text, images and audio-visual materials, copyrighted by Met Medical, not authorized by any media Websites or individuals may not be reproduced, and the authorizing reprints must include "Source: Metz Medicine".
all reprinted articles on this website are for the purpose of transmitting more information and clearly indicate the source and author, and media or individuals who do not wish to be reproduced may contact us and we will delete them immediately.
at the same time reproduced content does not represent the position of this site.
leave a message here