JNNP: Prediction of independent mortality in patients with frontal temporal degenerative syndrome

The prognosmation of dedefleitation (FTLD)-related syndromes in the frontal temporal lobe is highly variable and unpredictable.
The duration of the disease cannot be fully interpreted as a standard diagnostic classification of behavioral variant temporal lobe dementia (bvFTD), non-fluent frontal lobe dementia (nfvPPA), or synonym variation (svPPA) of primary aphdaffigation, carrying nucleotical paralysis (PSP) or cortical base artery syndrome (CBS).
a better prognosm model will help with trial design and clinical management.
syndrome caused by FLD has high heterogeneity and overlapping clinical characteristics.
subset of hypothetical clinical characteristics, representing the entire disease spectrum, explains changes in functional independence and survival rates.
, a cross-diagnosis method for mental and neurological disorders is used to determine the prognostic clinical characteristics of the entire FLD syndrome spectrum.
taking into account the heterogeneity of each syndrome associated with FLD and the esolysal overlap between syndromes, it is suggested that the presence of clinical characteristics will be more predictable than the prognosis of the diagnostic group.
combination of clinical characteristics is determined by the main component analysis rather than the diagnostic label, overcoming some of the limitations of the classification clinical diagnostic criteria.
a cross-diagnostic survival method was used in an epidemiological cohort in the UNITED Kingdom to test clinically diagnosed behavioral variability pretentiac dementia (bvFTD n=64), non-fluent variability primary regenerative adaffle (nfvPPA n=36) The relationship between clinical characteristics, independence, and survival rates in patients, semantic variant primary progenitic aphdplia (svPPA n=25), regenerative nuclear paralysis (PSP n=101) and cortical substrate artery syndrome (CBS n=68).
of the main components of the study identified six dimensions of clinical characteristics.
using Cox proportional risk and logistic regression, this paper determines the relationship between these dimensions and functionally independent survival rates (from clinical evaluation to nursing home hospitalization) and absolute survival rates (time of death).
analysis adjusted the covariables of age, gender and diagnostic groups.
secondary analysis excludes specific diagnostic groups.
The behavioral disorders assessed by clinicians and caregivers were associated with a shorter functional independent lifetime (OR 2.46, p.lt;0.001), while the presence of motor characteristics (including Parkinson's disease, posture instability, nuclear gaze paralysis, dystatic disorders, and debilication) was associated with a decrease in absolute survival.
these correlations can also be found in the FTLD-related common syndrome spectrum, even if typical groups associated with these clinical characteristics are excluded (bvFTD and PSP/CBS, respectively).
even if bvFTD patients are excluded from the analysis.
sports injuries were associated with reduced absolute survival, even though PSP and CBS patients were excluded from the analysis.
results are useful for individualized prediction and disease improvement trial planning, and support cross-diagnosis of disease treatment trials in patients with clinical syndrome combined with temporal lobe degeneration.
Murray AG, Rouse MA, Coyle-Gilchrist ITS, et al Predicting loss of independence and mortality in frontotemporal lobar degeneration syndromes Journal of Neurology, Neurosurgery Psython Published Online First: 09 February 2021. doi:10.1136/jnnp-2020-324903MedSci Original Source: MedSci Original Copyright Notice: All notes on this website "Source: Met Medical" or "Source: MedSci Original" text, images and audio-visual materials, copyrighted by Mace Medical, not authorized by any media Websites or individuals may not be reproduced, and the authorizing reprints must include "Source: Metz Medicine".
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