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Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS)
.
In most patients, the accumulation of focal lesions and the development of gray and white matter atrophy are associated with the development of progressive neurological dysfunction
It is assumed that the continued clinical improvement after alemtuzumab treatment will be reflected in the recovery of local electrophysiological and radiological indicators, especially abnormal electrophysiological and radiological indicators in MS, and the survival of axons in chronic demyelinating MS lesions.
Evidence of remyelination supports the idea that the reduction in disability observed after treatment with alemtuzumab cannot be explained by anti-inflammatory effects alone
.
Optic neuritis (ON) is the best model for testing the remyelination potential of therapeutics
In this paper, the visual pathway is used as a model to study the potential neuroprotection and remyelination effect of alemtumab
Changes in the average incubation period of patients and healthy controls
In patients, it was observed that the mfVEP latency was shortened by an average of 1.
21 milliseconds (95% CI 0.
21 to 2.
21, p=0.
013) during the entire study, unchanged due to changes in age, gender, course of disease, or T2 lesion volume
.
The average mfVEP latency of the HC group increased by 0.
After alemtuzumab treatment, there are signs of partial damage and remyelination.
The visual system provides a unique opportunity to study the functional and structural specific effects of the treatment
.
The visual system provides a unique opportunity to study the functional and structural specific effects of the treatment
.
WangC ,BartonJ , Kyle K Wang C Wang Barton J Barton Kyle K Kyle , et Al Multiple sclerosis: Structural and Functional Integrity of Visual System The following alemtuzumab Therapy Journal of.
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