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The prevalence of major depressive disorder (MDD) is 11%-14%, and one-third of patients are considered resistant to treatment
.
The prevalence of obsessive-compulsive disorder (OCD) is 2%–3%, and about one-third of patients are ineffective to the guideline treatment
The incidence of surgical or cognitive complications of these lesions is relatively low, and is an important treatment option for patients with long-term refractory diseases
.
The three most commonly used methods for ablation surgery are open surgery (radiofrequency ablation or radiofrequency ablation), stereotactic radiosurgery (SRS) or magnetic resonance guided focused ultrasound (MRgFUS)
The purpose of this article is to identify the effects of capsulotomy, cingulate incision, subcapsular bundle incision and marginal leukotomy on depression, obsessive-compulsive symptoms, and anxiety
Meta analysis steps
Meta analysis stepsThe title, abstract and full text were screened independently by two authors (BD and DE-J), and differences were resolved through consensus
.
A pre-registered systematic review of studies reporting clinical results after ablative neurosurgery was performed
Improved clinical outcome
Among the 943 articles, 43 studies reported data on 1414 patients, and included the comprehensive effect evaluation of the random effects meta-analysis
.
The results showed that depression improved greatly (g=1.
In summary, modern neurosurgery is significantly associated with improvements in depression, obsessive-compulsive symptoms, anxiety, and overall clinical impression
.
Neurology, Neurosurgery & Psychiatryin this message
