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JNNP: Factors affecting the early prognosis of patients with impulsive and compulsive behaviors treated by deep brain stimulation of the subthalamic nucleus

 Last Update: 2021-10-20
 Source: Internet
 Author: User

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Subthalamic nucleus (STN) deep brain stimulation (DBS) is a mature treatment for patients with advanced Parkinson's disease (PD), which can improve the quality of life, exercise and non-motor symptoms (NMS)
.

Specifically, STN-DBS can treat neuropsychiatric symptoms such as depression, anxiety, alexithymia, impulsive and compulsive behaviors

Existing data on DBS interventions for impulsive and compulsive behavior (ICB) have great methodological heterogeneity

Since STN-DBS usually leads to a significant reduction of dopaminergic drugs, that is, a reduction in the levodopa equivalent daily dose (LEDD), an improvement in ICB is observed after surgery
.

Studies have shown that the intervention of STN-DBS on ICB is complex, and understanding the factors that lead to changes in ICB is essential to improve the selection of patients with DBS

This article was published in " Journal of Neurology, Neurosurgery & Psychiatry " ( Journal of Neurology, Neurosurgery & Psychiatry )

This study is a prospective, observational clinical study, including PD patients receiving STN-DBS treatment
.

The diagnosis of Parkinson's disease is based on the British diagnostic criteria

This study is a prospective, observational clinical study, including PD patients receiving STN-DBS treatment

The impulsive obsessive-compulsive disorder questionnaire in the PD Rating Scale (QUIP-RS) evaluated the situation in the past 4 years

The study included 55 patients with ages of 61.
7 years ± 8.
4 years
.

The duration of PD is 9.

The study included 55 patients.

Patient questionnaire results

In the cohort study of this article, 39% of patients reported ICB at baseline.
The most common phenomenon was excessive hobbies, followed by eating disorders, excessive shopping, and excessive sexual behavior
.

These findings are consistent with previous studies in the DBS population

, 27.

SauerbierA ,LoehrerP ,Jost ST Sauerbier ASauerbier Loehrer PLoehrer Jost STJost, et alPredictors of short-term impulsive and compulsive behaviour after subthalamic stimulation in Parkinson diseaseJournal of Neurology, Neurosurgery & Psychiatry Published First: 11 September 2021.
Published Online First: doi: 10.
1136/jnnp-2021-326131doi:Leave a message here

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