JNNP: Effects of the lute syroid circuit on cognitive flexibility in patients with Huntington's disease: evidence from studies in young patients

Huntington's disease (HD) is a hereditary, rare neurodegenerative disease characterized by motor, cognitive and psychiatric symptoms.
HD is caused by the repeated expansion of the trinucleotide cytosine adenine (CAG) of the Huntington's Protein Gene (HTT) exon 1, which leads to the expression of the mutant form of the Huntington's protein.
cognitive flexibility is key to adaptive decision-making, as it is associated with the pre-frontal cortical layer (PFC) syroid circuit and is impaired in both explicit and early-oncology Huntington's disease (pre-HD).
neurodegenerativeness of the synth before HD and HD is particularly severe.
the purpose of this study was to examine the cognitive flexibility of a far-from-onset Huntington's disease (HD) queue to determine whether there was an early injury and, if so, whether the symposia circuit was associated with the defect.
method: In this study, the authors tested 51 HD subjects (average age: 29.22 years old) and 53 control groups with age, gender, and IQ matching, and tested additional dimension shift (IED) tasks within the Cambridge Neuropsychology Test (CANTAB).
this queue is unique because it is by far the most comprehensive study away from the age of onset of the disease (average year s 23.89 (standard deviation s 5.96) years).
IED task is to measure visual discernment, cognitive flexibility, and especially attention shift.
used a stationary functional MRI to check for abnormal functional connectivity between specific pre-synth circuits before HD compared to HD control.
result: CANTAB-IED tasks detect mild impairment of early cognitive flexibility.
attention transfer was significantly related to functional connections between the outer PFC and abdominal symposomes of the healthy control group and the functional connections between the outer PFC and tail bodies of former HD participants.
the CANTAB IED task detected mild impairment of cognitive flexibility in the pre-HD group far from the onset of the disease.
most of the pre-HD samples performed as well as the control group, but a few of the participants performed poorly.
in healthy individuals, functional connections between the outer PFC and the abdominal syroids were associated with cognitive flexibility.
In the HD pregroup, alternating amount-syroid circuits associated with attention-set shift may represent a form of functional recombination that, while effective for most HD pre-participants, is not appropriate in the few most affected pre-HD participants.
, the intrinsic link between HD patients with early cognitive impairment may provide potential cognitive flexibility.
authors speculate that early damage to this cognitive flexibility may be related to abnormal functional connections within the HD pre-frontal syroid circuit.
Langley C, Gregory S, Osborne-Crowley K, et al Fronto-Striatal circuits for cognitive flexibility in far from onset Huntington's disease: evidence from the Young Adult Study . Journal of Neurology, Neurosurgery and Psython Published Online First: 31 October 2020. doi: 10.1136/jnnp-2020-324104MedSci Original Source: MedSci Original Copyright Notice: All noted on this website "Source: Mace Medicine" or "Source: MedSci Original" text, images and audio and video materials, copyrights are owned by Metz Medicine, without authorization, no media, website or individual may reproduce, authorized to reproduce with the words "Source: Mets Medicine".
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