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JNNP: Comparative transcriptome-wide analysis of Parkinson's disease, focusing on the efficacy of zonisamide

 Last Update: 2022-04-22
 Source: Internet
 Author: User

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Zonisamide was originally developed as an antiepileptic drug and is an effective adjunct to Parkinson's disease patients, improving various symptoms, especially forgetfulness
.

In clinical settings, inter-individual differences in Parkinson's disease responsiveness to zonisamide are frequently observed, and a genome-wide association study ( GWAS ) was previously performed in Parkinson's disease patients to explain effects affecting zonisamide responsiveness genetic factors

The mechanisms underlying the inter-individual variation in GWAS zonisamide responsiveness have not been fully elucidated

Participants were selected from 220 Japanese patients with Parkinson's disease who participated in a previous clinical trial to approve zonisamide as an adjunct to levodopa therapy for "remission
.

" Blood samples for transcriptome sequencing were collected before starting treatment and 12 weeks after treatment

RNA was extracted from blood samples using the RNeasy mini kit (QIAGEN) following the manufacturer's protocol
.

RNA samples were tested for quality and quantity using an Agilent Technologies 2200 TapeStation

guide

DEGs gene differential expression analysis and GO-term enrichment analysis results

Of the well-documented clinical trial participants, only 25 and 26 met the SR and NR criteria, respectively
.

Additionally, three of the 51 participants failed RNA sample collection or RNA quality tests

Of the well-documented clinical trial participants, only 25 and 26 met the SR and NR criteria, respectively

Significant enrichment of zonisamide by DEGs between SRs and NRs in PD patients was found to have multiple biological functions, providing meaningful insights

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