JNNP: Brain magnetic resonance diagnosis of MOG antibody-related diseases and AQP4 antibody-related diseases

Autoantibodies to antimalial glial glial glycogen (MOG) are present in inflammatory diseases such as optic neuroscolonitis spectrum disorder (NMOSD), acute spreading encephalopathy (ADEM), optic neuritis, and transverse myocarditis.
diagnosis is difficult because of similar clinical and imaging characteristics.
In the MOGADOR study, adult patients with MOG-Ab-related diseases (MOGAD) had the highest risk of lesions in the lesions of the pasum and brain bridge, but another study showed that changes in MOGAD disease were common in the subsurfic white matter and inner sac, while cerebral bridge lesions did not show significant manifestations.
in pediatric patients, cer cerebral foot lesions are the majority in MOGAD, but there is no statistically significant difference between brain bridge, pausc and cortical lesions.
may indicate a significant difference in the range of disease and the age of onset.
study, the brain regions of interest were divided into 21 identified parts and the lesions distribution of MOGAD and NMOSD was analyzed.
registered 134 MOGAD patients and 70 NMOSD patients, brain MRI scans, including T2 weighted and fluid attenuation reversal recovery sequences, have been obtained using a 3.0/1.5t scanner.
an independent neurologist and a blind neuroradiologist, an MRI assessment by the Brain Lesology Department.
in the absence of agreement, the final decision was based on a consensus between the two evaluating staff.
to better show the prevalence and location of brain-dry lesions in patients with MOGAD and NMOSD, the authors used Adobe Photoshop (Adobe, California, USA) to overlay MRI images of brain-dry lesions in patients.
the medium age of MRI was 23 years (9-42 years) in the MOGAD group and 47 years (33-63 years) in the NMOSD group .001.
53 cases in the MOGAD group and 4 cases in the NMOSD group for children under 18 years of age.
MOGAD group 53.7% and NMOSD group 87.1% are female (p.lt;0.005).
the NMOSD group EDSS is higher than the MOGAD group (p.lt;0.005).
in 103 (76.9%) MOGAD patients and 49 (70.0%) NMOSD patients, brain damage was found on MRI at the time of onset (p-0.369).
men with MOGAD had significantly more white lesions (23.1%) and small brain feet (22.4%) than NMOSD patients (0.0% and 4.3%, respectively).
the risk of spinal backside lesions (30.0%) in the NMOSD group was higher than in the MOGAD group (6.0%, p.lt;0.001).
two groups, there was no significant difference in lesions found in the other 18 regions.
compared to NMOSD, the positive and negative ratios of MOGAD (95% CI) were 5.22 (1.65 to 16.52) and 0.81 (95% CI) in the cer cerebral foot, respectively. 0.73 to 0.90), 0.20 (0.09 to 0.43) and 1.34 (1.15 to 1.58) on the back of the spinal cord, respectively.
no statistical difference between brain injury and radon strengthening in both diseases (p-0.238).
proportion of spreading lesions occurring simultaneously in the MOGAD group (108 out of 134 cases) was higher than that of the NMOSD group (30 out of 70 cases, p.lt;0.001).
images of brain dry lesions in patients with MOGAD and NMOSD show that cone and endomeeal lesions are common in MOGAD patients, while rear area lesions are observed in patients with MOGAD.
current research shows that small brain foot lesions greatly increase the likelihood of MOGAD, but do not increase the likelihood of NMOSD, on the contrary, spinal backside lesions increase the likelihood of NMOSD, but do not increase the likelihood of MOGAD.
specific anatomical regions associated with antibodies that are easily accessible to antigens, such as organs around the chamber in NMOSD, including the last region, were not observed in MOGAD.
contrary, high-density myelin may be associated with MOGAD, as the foot of the brain is the starting point for myelin formation during brain development, which is likely to indicate that it is a site that maintains high levels of myelin throughout an individual's life.
Matsumoto Y, Misu T, Mugikura S, et al-Profile lesions of brain MRI between MOG-antibody-associated and AQP4-antibody-associated diseases Journal of Neurology, Neurosurgery Psython Published Online First: 30 December 2020. doi:10.1136/jnnp-2020-324818MedSci Original Source: MedSci Original Copyright Notice: All notes on this website "Source: Met Medical" or "Source: MedSci Original" text, images and audio-visual materials, copyrighted by Met Medical, not authorized by any media Websites or individuals may not be reproduced, and the authorizing reprints must include "Source: Metz Medicine".
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