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The brain of children with multiple sclerosis (pedMS) is affected by high swelling and axon degeneration
.
Diffusion tensor imaging reveals the structural changes of pedMS normal white matter (NAWM), and further emphasizes that MRI visible white matter (WM) lesions cannot reflect the full extent of MS tissue damage
In this study, NODDI was used to study the existence of early microstructural damage in pedMS and compared with a set of matched healthy controls (HC) to study its correlation with physical disability and WM lesion volume (LV)
19 patients with relapsed pedMS
.
Eight patients received no treatment; the rest of the patients received stable treatment with Natalizumab
Overview of image acquisition, processing and main results
The median values of different NODDI indicators are then extracted from the NAWM and HC-WM of the patient, as well as the specific LV of each segment
.
The differences in age and gender were evaluated by two-sample t-test and χ2 test
In the pedMS cohort, MS-related pathology was observed to have a significant impact on tissue integrity in the so-called NAWM
.
Compared with DTI, a major advantage of NODDI is that it can separate the contribution of axon/dendritic density and fiber orientation to microscopic changes
The lack of correlation between NDI and EDSS scores is expected, which may indicate that in the early stages of MS, disability is mainly caused by inflammation and demyelination
.
Inflammation-induced neurodegeneration is expected to lead to the accumulation of physical and cognitive dysfunction in the later stage of the disease.
In conclusion, NODDI revealed significant microstructural changes in NAWM of pedMS, and further provided in vivo evidence to support the hypothesis that inflammation-induced neurodegeneration affects the MS brain since the biological onset of the disease
.
MargoniM ,Villanithe U- ,FinosL MargoniM Margoni Villanithe U- Villani FinosL Finos , et Al Neurite Orientation Dispersion and Density Imaging discloses Early Changes in The Normal-appearing White Matter in Pediatric Multiple sclerosis Journal of.
Neurology, Neurosurgery & Psychiatry in this message
