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Jiahe Biotech EGFR/c-Met/c-Met trispecific antibody applied for clinical application

 Last Update: 2022-04-23
 Source: Internet
 Author: User

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Article source: Medical Cube Info

On March 29, CDE's official website showed that Jiahe Bio's application for clinical trials of EGFR/c-Met/c-Met trispecific antibodies in China was accepted by the State Food and Drug Administration

GB263T is the world's first EGFR/c-Met/c-Met trispecific antibody, targeting EGFR and two different c-Met epitopes

In vitro studies and in vivo animal models have demonstrated its antitumor activity

The antitumor activity of GB263T was evaluated in multiple tumor models including Ba/F3 EGFR-D770del-insGY, Ba/F3 EGFR-D770-N771-insSVD, Ba/F3

EGFR-ex19del/T790M/C797S, HCC827/ER1, LU2503 PDX model (c-Met exon 14 skipping mutation), etc.

In the cynomolgus monkey toxicology study, even in the high-dose group, no significant adverse reactions were observed after 4 weeks of administration

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