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Jia Hao, associate researcher of the Department of Biochemistry and Molecular Cell Biology, School of Basic Medicine, recently published a paper entitled "LncRNA IFITM4P is activated through LPS/TLR4 and promotes immune escape by up-regulating PD-L1 via dual mechanism in the journal Molecular Therapy.
Oral leukoplakia (oral leukoplakia) is one of the most important potential malignant diseases of oral mucosa, and its pathological features are abnormal epithelial hyperplasia
Using high-throughput screening of oral leukoplakia tissue and oral squamous cell carcinoma tissue samples, the researchers found that the expression level of PD-L1 increased with the increase of tissue malignancy
The team's researchers further used high-throughput genetic screening to find that compared with normal tissues, the long-chain non-coding RNA IFITM4P was highly expressed in human oral leukoplakia/squamous cell carcinoma tissues, and its expression level increased with the degree of malignancy.
Shi Linjun, deputy chief doctor of the Department of Oral Mucosal Diseases, Affiliated Ninth People's Hospital, Yang Yuquan, a master student in the Department of Biochemical Cells, School of Basic Medicine, and Li Mengying, a doctoral student, are the co-first authors of the paper; Associate Researcher Jia Hao, Researcher Hou Zhaoyuan and Affiliated No.
