JE: Qingluo Tongbi Recipe alleviates liver damage caused by Tripterygium wilfordii

Background: Tripterygium wilfordii is clinically used for the treatment of autoimmune diseases and inflammatory diseases , such as rheumatoid arthritis, systemic lupus erythematosus and immune nephropathy, etc.

In traditional Chinese medicine, Tripterygium wilfordii is often taken orally in combination with one or more traditional Chinese medicines to reduce possible adverse reactions through synergistic effects

QLT is composed of five ingredients: Tripterygium wilfordii, Panax notoginseng powder, Rehmannia glutinosa, Qingfengteng, and Chili silkworm

OBJECTIVE: To investigate whether Tripterygium wilfordii interferes with lipid metabolism to induce liver injury, and to evaluate the protective effect of Qingluo Tongbi Prescription in in vivo and in vitro experiments

Methods: After administration, the biochemical indexes, lipid changes of hepatocytes and liver pathological changes of heparin cells and SD rats were detected, and liver X receptor α ( LXRα) , endoplasmic reticulum stress key protein and sterol regulatory element binding protein were analyzed.

Results: After 25.

Tripterygium wilfordii significantly upregulated the expression of LXRα and GRP78 genes, and significantly increased the mRNA levels of key UPR sensors ATF6 and IRE1, suggesting that Tripterygium wilfordii upregulated the expression of LXRα gene and triggered ER stress in HepaRG cells

Conclusion: Tripterygium wilfordii up- regulates LXRα to activate endoplasmic reticulum stress , increase the gene expression of SREBP-1c and lipid synthase, and lead to increased lipid synthesis in hepatocytes, which in turn leads to liver injury

Source:

Yu, Z.