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JCO: The effect of oral azacitidine on patients with low-risk myelodysplastic syndromes

 Last Update: 2021-04-14
 Source: Internet
 Author: User

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Recently, the Journal of Clinical Oncology published a study online that showed that although CC-486 can increase the proportion of patients with LR-MDS that do not rely on red blood cell transfusion, it may increase the risk of early death.

Screenshot of the cover of the paper

Myelodysplastic Syndrome (MDS) covers a group of blood system diseases characterized by myelodysplastic proliferation and peripheral blood cytopenia.

The experiment recruited patients from 101 locations in 20 countries/regions from April 2013 to February 2018.

Technical route

CC-486 can reduce the blood transfusion burden of RBC and improve thrombocytopenia in LR-MDS patients with symptomatic diseases and refractory cytopenias, but the CC-486 group has a higher incidence of early death

references:

Garcia-Manero G, Santini V, Almeida A, Platzbecker U, Jonasova A, Silverman LR, Falantes J, Reda G, Buccisano F, Fenaux P, Buckstein R, Diez Campelo M, Larsen S, Valcarcel D, Vyas P, Giai V , Olíva EN, Shortt J, Niederwieser D, Mittelman M, Fianchi L, La Torre I, Zhong J, Laille E, Lopes de Menezes D, Skikne B, Beach CL, Giagounidis A.

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