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JCO: Can recurrent ovarian cancer benefit from carboplatin intraperitoneal hyperthermic perfusion chemotherapy during secondary cytoreductive surgery?

 Last Update: 2021-05-31
 Source: Internet
 Author: User

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In 2021, the United States is expected to add 21,410 new cases of ovarian cancer , and about 13,770 women will die of ovarian cancer.

Ovarian cancer

This study aimed to evaluate the efficacy of carboplatin hyperthermic intraperitoneal perfusion chemotherapy (HIPEC) in patients with recurrent ovarian cancer during secondary cytoreductive surgery .

This study aims to evaluate the efficacy of carboplatin intraperitoneal hyperthermic perfusion chemotherapy (HIPEC) in patients with recurrent ovarian cancer during secondary cytoreductive surgery.

98 subjects randomly received carboplatin HIPEC (HIPEC group, 800 mg/m2, for 90 minutes) or no HIPEC (standard treatment group) intraoperatively.

A total of 98 patients, 49 in each group.

There were no perioperative deaths, and there were no differences in the use of ostomy, hospital stay or postoperative toxicity between the two groups.

At 24 months, 8 patients in the HIPEC group did not progress or died, while 12 patients in the standard treatment group

PFS and OS of the two groups

During the mid-term follow-up of 39.

The median HIPEC group and the standard treatment group progression-free survival was 12.

Carboplatin for intraperitoneal hyperthermic infusion chemotherapy is well tolerated in patients with recurrent ovarian cancer, but it does not produce a good clinical prognosis

Original source:

Oliver Zivanovic, et al.

org/10.
1200/JCO.
21.
00605" target="_blank" rel="noopener">Secondary Cytoreduction and Carboplatin Hyperthermic Intraperitoneal Chemotherapy for Platinum-Sensitive Recurrent Ovarian Cancer: An MSK Team Ovary Phase II Study

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