JCI: Vitamin C can inhibit the production of tumor stem cells!

February 22, 2019 / BIOON / - cancer, is a word that makes people smell color change, and makes people feel fear and anxiety So many women with cancer and treatment experience chronic stress and depression Scientists have found in experiments in humans and rodents that stress accelerates cancer progression, but it's not clear what's behind it Photo source: JCI and a recent study published in Journal of clinical investigation by Dalian Medical University and Zhongshan University revealed the secret: the stress hormone adrenaline triggered a series of biochemical reactions, leading to the growth and metastasis of cancer cells In this study, the researchers first showed the effect of chronic stress on the growth of cancer stem cells, which was not the focus of previous studies Using an immune deficient mouse model, the researchers found that chronic stress-induced adrenaline promoted the production of cancer stem cell like properties in breast cancer cells, mainly by resetting the metabolic pathway dependent on lactate dehydrogenase A (aldha) Adrenaline induced by chronic stress can activate ldhA to produce lactate and change pH, which will lead to USP28 mediated myc ubiquitination and enhance its stability Slug enhancers are then activated by Myc, which causes cancer cells to produce breast cancer stem cell like properties Using drug screening tests targeting ldhA, the researchers found that vitamin C reversed a stem cell like feature of chronic stress-induced stress These findings indicate the importance of physiological factors in promoting the production of stem cell like properties in breast cancer cells Therefore, vitamin C, which can inhibit ldhA, may be an effective drug against stress-related breast cancer Reference materials: Bai Cui et al Stress induced epmenine enhances lacerate dehydrogenase A and promotes breast cancer stem like cells, Journal of clinical investigation (2019) Doi: 10.1172/jci121685