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Although inflammation is associated with kidney function in diabetic patients, the possible link between inflammation and renal function in newly diagnosed diabetes is not clear.
recently, a research paper was published in Journal of Clinical Endocrinology and Metabolism, an authoritative journal in the field of endocrine and metabolic diseases, to investigate the cross-sectional and forward-looking associations between inflammation and biomarkers of kidney function in newly developed diabetics.
the study included people with type 1 and type 2 diabetes who developed type 1 and type 2 diabetes for one year in the German Diabetes Study (GDS).
researchers measured baseline serum concentrations of 74 biomarkers using proximity extension analysis techniques and used polylinear and Logistic regression analysis to assess their association with estimated renal cystic filtration rate (eGFR) and decreased renal function over five years.
cross-sectional analysis included 165 people with type 1 diabetes and 291 people with type 2 diabetes.
, the baseline eGFR for people with type 1 diabetes is higher than in patients with type 2 diabetes (102 x 5 vs. 90 x 6 mL/min/1.73m2; p=0.0001).
after comprehensive adjustment of covariances and multiple tests, 7 biomarkers in type 1 diabetics were associated with lower baseline eGFR and 24 biomarkers in type 2 diabetes were associated with lower baseline eGFR.
of these biomarkers, six biomarkers (CD5, CCL23, CST5, IL-10RB, PD-L1, and TNFRSF9) were negatively associated with eGFR in two diabetic patients.
-looking analysis found no association between inflammatory biomarkers and decreased renal function.
found no evidence of an interaction between type diabetes and inflammatory biomarkers.
result, several inflammatory biomarkers were associated with lower baseline eGFR in patients with new type 1 and type 2 diabetes, but not with loss of renal function within the first five years of diabetes diagnosis.
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