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JCEM: Changes of serum cytokines in women with polycystic ovary syndrome during pregnancy

 Last Update: 2021-09-29
 Source: Internet
 Author: User

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Polycystic ovary syndrome (PCOS) is a common endocrine disease, which is related to low-grade inflammation and increased incidence of pregnancy complications, but its influence on the maternal immune system during pregnancy is not yet clear
.

immunity

Recently, the Journal of Clinical Endocrinology & Metabolism, an authoritative journal in the field of endocrine and metabolic diseases, published a research article.
Pregnancy was compared
.

The researchers performed post hoc analyses of longitudinal serum samples from two randomized, placebo-controlled multicenter studies of pregnant women with PCOS and two studies of non-PCOS pregnant women
.

PCOS pregnant women (n=358) and non-PCOS pregnant women (n=258, control group) provided 1752 serum samples at four time points (10th, 19th, 32nd, and 36th weeks) during pregnancy

The immunological changes of serum cytokines in women with PCOS are more significant throughout pregnancy
.

Compared with the control group, the levels of 17 cytokines and CRP in pregnant women with PCOS increased during the 10th week of pregnancy, and there were obvious cytokine changes throughout the pregnancy

Pregnancy in PCOS women is associated with strong early inflammatory mobilization and other serum cytokines.
These cytokines persist throughout the pregnancy, indicating a more active immune state

Original source:

Live Marie T Stokkeland.

et al.
Changes in serum cytokines throughout pregnancy in women with polycystic ovary syndrome .

Changes in serum cytokines throughout pregnancy in women with polycystic ovary syndrome in this message

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