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JBMR: The effect of Odanacatib on bone structure and quality of postmenopausal women with osteoporosis

 Last Update: 2021-09-10
 Source: Internet
 Author: User

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Odanacatib (ODN) is an oral selective cathepsin K (CatK) inhibitor for osteoporosis.

Compared with placebo, the proportion of periosteal double-label patients and bone formation index in ODN-treated patients increased over time

In summary, ODN treatment for 5 years did not reduce bone remodeling, and increased the proportion of patients with periosteal bone formation .

ODN treatment for 5 years did not reduce bone remodeling, and increased the proportion of patients with periosteal bone formation .

Source: Robert Recker, MD1, David Dempster, PhD2, Bente Langdah, Effects of Odanacatib on Bone Structure and Quality in Postmenopausal Women with Osteoporosis: 5-year Data from the Phase 3 Long-Term Odanacatib Fracture Trial (LOFT) and its Extension , J Bone Miner Res 2020 07;35(7)

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