JASN: Childhood Cancer and ESKD Risk

Increased incidence of childhood cancer and improved treatment have led to an increasing number of childhood cancer survivors.
that although childhood cancer survivors are exposed to a variety of factors that impair kidney function, few studies have investigated the relationship between childhood cancer and future kidney disease.
recently published a study in Journal of the American Society of Nephrology, an authoritative journal in the field of kidney disease, to assess the risk of ESKD in childhood cancer survivors.
researchers conducted a population-based national retrospective queue study that included all adolescents assessed for compulsory military service in Israel from 1967 to 1997.
after obtaining detailed historical data, the researchers divided the queue into three groups: subjects with no tumor history, a history of benign tumors (non-malignant tumors with impaired function), and a history of malignant tumors (excluding kidney cancer).
database has been linked to the Israeli ESKD Registry to determine the ESKD event.
researchers used the Cox Scale Risk Model to estimate the risk ratio (HR) of ESKD.
of the 1468,600 participants in the group, 1444,345 had no tumor history, 23,282 had a benign tumor history, and 973 had a history of malignant tumors.
2,416 (0.2%) participants without a history of tumors developed ESKD during an average follow-up period of 30.3 years.
Although benign tumor history was not associated with increased risk of ESKD, participants with a history of malignant tumor disease increased significantly compared to participants without a history of tumor disease (adjusted HR was 3.2; 95 percent confidence interval was 1.3 to 7.7) after controlling age, sex, age, age, and patriarchal origin.
, childhood cancer is associated with an increased risk of ESKD, suggesting a more rigorous and longer follow-up to kidney disease.