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JAMA sub-journal: Study of more than 20,000 people finds that LDL-C less than 1.
JAMA
A recent meta-analysis published in JAMA Neurology found that low-density lipoprotein cholesterol (LDL-C)-lowering statin therapy may reduce the risk of recurrent stroke in patients with a history of ischemic stroke, but The risk of hemorrhagic stroke is increased
Low-density lipoprotein cholesterol (LDL-C)-lowering statin therapy may reduce the risk of recurrent stroke but increase the risk of hemorrhagic stroke
Meng Lee et al, Association Between Intensity of Low-Density Lipoprotein Cholesterol Reduction With Statin-Based Therapies and Secondary Stroke Prevention, JAMA Neurology (2022).
Meng Lee et al, Association Between Intensity of Low-Density Lipoprotein Cholesterol Reduction With Statin-Based Therapies and Secondary Stroke Prevention, JAMA Neurology (2022).
Higher-intensity LDL-C-lowering statin therapy was associated with a lower risk of recurrent stroke compared with lower-intensity LDL-C-lowering statin therapy.
Higher-intensity LDL-C-lowering statin therapy was associated with a reduced risk of major cardiovascular events but an increased risk of hemorrhagic stroke .
In patients with a history of ischemic stroke, intensive statin-based lipid-lowering therapy to reduce LDL-C levels to <1.
"The message to clinicians is to reduce LDL cholesterol levels below 70 mg/dL by any means after ischemic stroke in patients with evidence of atherosclerosis,
References:
Meng Lee et al, Association Between Intensity of Low-Density Lipoprotein Cholesterol Reduction With Statin-Based Therapies and Secondary Stroke Prevention, JAMA Neurology (2022).
Meng Lee et al, Association Between Intensity of Low-Density Lipoprotein Cholesterol Reduction With Statin-Based Therapies and Secondary Stroke Prevention, JAMA Neurology (2022).
DOI: 10.
1001/jamaneurol.
2021.
5578
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