JAMA Sub-Journal: Don’t go for exercise yet—the evidence that physical activity can slow down cognitive decline is here again!

Tau is abnormally phosphorylated in the brains of Alzheimer's disease (AD) patients and is a potential target for AD treatment or intervention
.

The increase in the concentration of total tau in plasma is related to the decline of cognitive ability, especially in memory, cognition, visuospatial ability, attention and the progression from mild cognitive impairment to AD

Increased plasma concentrations of total tau and the related cognitive decline, especially in memory, cognition, visual spatial ability, attention disorders as well as progress from mild cognitive aspects to AD plasma concentrations of total tau and increase awareness Ability decline is related, especially in memory, cognition, visuospatial ability, attention, and progression from mild cognitive impairment to AD

However, studying whether the preventive factors of individuals with high total tau concentration are related to slower cognitive decline is an important issue for disease prevention
.

Scientists are full of interest in the long-term preclinical interventions of AD, such as participating in sports activities, which have a positive impact on the disease before clinical symptoms appear

Prevention scientists are full of interest in the prolonged preclinical stage of AD interventions, such as participating in sports activities, which have a positive impact on the disease before clinical symptoms appear

Generally speaking, physical activity can prevent the decline of cognitive ability, reduce the chance of suffering from AD, and slow down the occurrence of dementia
.

The increase in physical activity is also associated with higher hippocampus and total brain volume and a decrease in age-related neuroimaging biomarkers

Generally speaking, physical activity can prevent the decline of cognitive ability, reduce the chance of suffering from AD, and slow down the occurrence of dementia

JAMA

The Chicago Health and Aging Project is a population-based cohort study conducted in 4 Chicago communities
.

The data was collected in a three-year cycle from 1993 to 2012

Exposure factors were the participants' physical activity and serum total tau concentration
.

The physical activity data is obtained through a self-report project, and the total number of minutes per week is calculated

Annual changes in cognition grouped by physical activity and total Tau concentration

Among the 1159 participants in the study, 728 were women (63%) and 696 were African American (60%); the average (SD) age was 77.
4 (6.
0) years, and the average (SD) education level was 12.
6 ( 3.
5) Years
.

In general, participants with high total tau concentration and moderate physical activity had a 58% slower rate of cognitive decline, and those who had a lot of physical activity, compared with those who had less physical activity, The rate of cognitive decline is 41% slower

In general, participants with high total tau concentration and moderate physical activity had a 58% slower rate of cognitive decline, and those who had a lot of physical activity, compared with those who had less physical activity, The rate of cognitive decline is 41% slower

Among participants with a low total tau concentration, moderate physical activity was associated with a 2% slower rate of cognitive decline, while high physical activity was 27% slower than low physical activity

Stratified by the concentration of total Tau, the relationship between physical activity and the rate of decline in overall cognitive ability

The researchers point out that the results support the potential utility of blood biomarkers in measuring the benefits associated with healthy behaviors, and may help target populations or provide interventions for trials that focus on improving physical activity behaviors
.
Future work should study the relationship between total tau concentration and other types of health behaviors and physical activity
.

This study showed that in participants with high and low total tau concentrations, physical activity was associated with slower cognitive decline
.

This study showed that in participants with high and low total tau concentrations, physical activity was associated with slower cognitive decline
.
This study showed that in participants with high and low total tau concentrations, physical activity was associated with slower cognitive decline
.

 

references:

Longitudinal Association of Total Tau Concentrations and Physical Activity With Cognitive Decline in a Population Sample.
JAMA Netw Open.
2021;4(8):e2120398.
doi:10.
1001/jamanetworkopen.
2021.
20398

Longitudinal Association of Total Tau Concentrations and Physical Activity With Cognitive Decline in a Population Sample.
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