JAMA Sub-Journal: Attention, too much sleep and too little sleep are all related to depression and Alzheimer's!

Sleep disorders are common among elderly people and are related to cognitive ability
.

Age-related sleep-related changes with a variety of reasons, including early pathology of Alzheimer's disease (amyloid β [Aβ]), depression and cardiac vascular diseases

Sleep disorders are common among elderly people and are related to cognitive ability

JAMA

This cross-sectional study obtained data from participants in the anti-amyloid treatment (A4) study of asymptomatic Alzheimer's disease, which was conducted in 67 locations in the United States, Canada, Australia, and Japan
.

The analyzed samples included people aged 65-85 who underwent Aβ positron emission tomography (PET), had complete lipoprotein E (APOE) genotype data, and were determined to be clinically normal (according to a clinical dementia score of 0 ) And cognitive accessibility (according to the mini-mental state check score of 25 to 30, and the logical memory delayed recall test score of 6 to 18)

The main result is the self-reported night sleep time (according to short-term sleep time: ≤6 hours, normal sleep time.

7-8 hours, and long sleep time: ≥9 hours), and related to demographic characteristics, Aβ burden (with fluorine 18-labeled fluorobetapine PET scan measurement), objective and subjective cognitive function measurements, and life>
.

The 4,417 participants in the study included 2,618 women (59%), with a mean (SD) age of 71.

3 (4.

The self-reported shorter sleep time has a linear relationship with the higher Aβ burden (β [SE] = -0.

Sleep time is related to Aβ burden

Sleep time is related to Aβ burden

However, compared with normal sleep time, both short and long sleep time are associated with a higher BMI index (short and normal sleep time: β [SE] = 0.
48 [0.
17]; long and normal sleep time: β [SE] = 0.
97 [0.
31]), depressive symptoms (short and normal sleep time: β[SE]=0.
31[0.
05]; long and normal sleep time: β[SE]=0.
39[0.
09]), daytime naps (short and Normal sleep time: β[SE]=2.
66[0.
77]; long is related to normal sleep time: β[SE]=3.
62[1.
38]) and poor performance in multiple cognitive domains
.

Compared with normal sleep time, both short and long sleep time are associated with a higher BMI index (short and normal sleep time: β [SE] = 0.
48 [0.
17]; long and normal sleep time: β [SE] = 0.
97 [ 0.
31]), depressive symptoms (short and normal sleep time: β[SE]=0.
31[0.
05]; long and normal sleep time: β[SE]=0.
39[0.
09]), daytime naps (short and normal sleep Time: β[SE]=2.
66[0.
77]; long is related to normal sleep time: β[SE]=3.
62[1.
38]) and poor performance in multiple cognitive domains
.

Compared with normal sleep time, both short and long sleep time are associated with a higher BMI index (short and normal sleep time: β [SE] = 0.

It can be seen that too long or too short sleep time (sleep time ≤ 6 hours or sleep time ≥ 9 hours) are related to worse results in the elderly, such as greater Aβ burden, more depressive symptoms, and higher The decline in BMI index and cognitive ability emphasizes the importance of maintaining adequate sleep

references:

Winer JR, Deters KD, Kennedy G, et al.

Association of Short and Long Sleep Duration With Amyloid-β Burden and Cognition in Aging.
JAMA Neurol.
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