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For infants born weighing less than 1000 grams, red blood cell infusion therapy is usually performed clinically, but the amount of blood transfusion is not yet fully studied.
previous studies have shown that lower blood transfusions appear to be associated with a risk of cognitive impairment.
recently examined the correlation between red blood transfusions in low-weight newborns and death or disability.
The study was conducted in 36 neonatal intensive care centers in Europe, with a total of 1,013 infants born weighing between 400 grams and 999 grams entering the group within 72 hours of birth, of whom 492 were not restricted by red blood cell transfusions (free infusion groups) and 521 children were limited by red blood cell transfusions (restricted infusion groups).
end of the study was death or disability at 24 months (any cognitive impairment, cerebral palsy or severe visual or hearing impairment).
secondary endpoints are prenatal complications and growth and development.
the average age of birth was 26.3 weeks, with 50.2 per cent of girls and 91.6 per cent of participants completing the study.
in the free blood transfusion group and the restricted blood transfusion group, the blood transfusion rates were 81.3% and 60.5%, respectively, with an average blood transfusion of 40 ml and 19 ml, respectively.
200 children with free infusions had major endpoint events (44.4%), while 205 children in the restricted infusion group had endpoint events (42.9%) and 38 deaths within 24 months (8) .3%) and 44 (9.0%), cognitive impairment 154 (37.6%) and 148 (34.4%) respectively, and cerebral palsy 18 (4.3%) and 25 cases (5.6%), 20 cases (4.1%) and 28 (5.4%) of necrotization colitis requiring surgical treatment, and 130 cases of bronchopulmonary dysplasia, respectively (28.4 per cent) and 126 (26.0 per cent), respectively, 41 (8.7 per cent) and 38 (7.7 per cent) of premature children required treatment.
study found that for babies born weighing less than 1,000 grams, not limiting red blood cell infusions did not reduce the risk of death or disability at 24 months.
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