JAMA Psychiatry: Hypothyroidism may cause depression!

Hypothyroidism is a clinical condition caused by insufficient secretion of thyroid hormones ( T4 ) and triiodothyronine ( T3 )
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Most cases belong to primary hypothyroidism, that is, the thyroid cannot produce thyroid hormones

Hypothyroidism is a clinical condition caused by insufficient secretion of thyroid hormones ( T4 ) and triiodothyronine ( T3 )

Hypothyroidism is considered to be the cause of depression or a strong risk factor Hypothyroidism is considered to be the cause or strong risk factor of depression

In order to assess the association between hypothyroidism and clinical depression in the general population, experts from the Department of Psychiatry and Psychotherapy at the University of Cologne Medical School in Germany conducted a meta-analysis study, and the results were published in the recent JAMA Psychiatry journal
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JAMA

Researchers searched the PubMed, PsycINFO and Embase databases for research on the association between hypothyroidism and clinical depression as of May 2020
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Followed by two reviewers independently selected studies epidemiology and population-based, these studies provide hypothyroidism laboratory or international statistical classification of diseases and related health problems diagnosis , and according to operational criteria (such as "mental illness Diagnosis and Statistics Manual" DMS or International Statistical Classification of Diseases and Related Health Problems) or the cut-off point of the established score scale to diagnose depression

diagnosis

Data extraction Two reviewers independently extracted data and evaluated the study according to the Newcastle-Ottawa scale
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Calculate the odds of aggregation (OR) in a meta-analysis of random effects

immunity

Results Among the 4350 articles screened, 25 studies were selected for the meta-analysis, including 348,014 participants
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In general, hypothyroidism increases the risk of clinical depression by 30% (OR=1.

In general, hypothyroidism increases the risk of clinical depression by 30% (OR=1.

The relationship between hypothyroidism and depression

Subgroup analysis showed that compared with overt hypothyroidism, the risk of depression is more strongly associated with subclinical hypothyroidism.
The risks of the two are 77% and 13%, respectively
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In a post-hoc analysis, this association was confirmed in female individuals (OR=1.

Subgroup analysis showed that compared with overt hypothyroidism, the risk of depression is more strongly associated with subclinical hypothyroidism.

In summary, in this systematic review and meta-analysis, hypothyroidism is significantly related to depression, especially increasing the risk of depression in women

references:

Association of Hypothyroidism and Clinical Depression: A Systematic Review and Meta-analysis.

Association of Hypothyroidism and Clinical Depression: A Systematic Review and Meta-analysis.
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