JAMA Neurology: New study reveals effective molecules for relieving nerve pain

October 18, 2020 /--- more than 20 million people in the United States suffer from neuropathic pain.
25 percent of these cases are classified as unsealable and considered recessive sensory multiple neuropathy (CSPN).
there is no information to guide physicians in choosing CSPN drugs, but researchers at the University of Missouri School of Medicine and MU Health Care conducted the first prospective comparative effectiveness study.
the study compared four drugs with different action pathopaths in a large number of CSPN patients to determine which drug was best suited for the condition.
the study involved 40 locations and recruited 402 patients over the age of 30 who were diagnosed with CSPN with a pain score of 4 or higher on a 10-point scale.
(Photo source: www.pixabay.com) participants were treated with one of CSPN's four commonly used drugs: demethyltin (a tricycular antidepressant); dolositin (a 5-serotonin depylamin reuptake inhibitor); Pribarin (an anti-epileptic drug); or methicillin (a drug that fights arrhythroids).
patients received the prescribed treatment for 12 weeks and were assessed at 4, 8 and 12 weeks.
any participant who reported pain reduction of at least 50 percent was considered to have proven effective results.
also measured patients who had their medication discontinued due to adverse reactions.
. Richard Barohn, lead researcher and executive vice president of health affairs at the University of Missouri, said, "This study goes beyond whether drugs can reduce pain and focuses on side effects."
As the first of its kind, we compared these four drugs in real life to provide evidence to doctors to support the effective management of peripheral neuropathy and to support the need for newer, more effective drugs for nerve pain.
study found that the highest percentage of effectiveness (25%) and the second 2nd 1st (38%) smoking cessation rate were the most effective overall.
the second highest rate (23 per cent) and the lowest drop-out rate (37 per cent).
the lowest efficacy (15%), while methicillin had the highest rate of smoking cessation (58%).
there are any significantly superior drugs in this study," said Barohn, a professor of drugs.
, however, of the four drugs, the effects of d'acetatin and doloxitin were better when both efficacy and withdrawal were considered.
, we recommend that we consider taking methicillin or doloxitin before we test other drugs.
"there are other non-anaesthetic drugs used to treat peripheral nerve pain, including gaba sprays, venlafasin and other sodium channel inhibitors."
said more comparative effectiveness studies could be done on these drugs, so doctors could further build a database to treat CSPN.
goal is to build data on the effectiveness of nearly a dozen drugs for CSPN.
(bioon.com) Source: Study reveals most effective drugs for common type of of neuropathic pain Original source: Richard J. Barohn et al, Assisted Interventions for Neuropathy: Comparison of Treatment in Real Life Situations (PAIN-CONTRoLS), JAMA Neurology (2020). DOI: 10.1001/jamaneurol.2020.2590