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JAMA Neurology: How effective is antiplatelet therapy for stroke after cerebral hemorrhage?

 Last Update: 2021-09-29
 Source: Internet
 Author: User

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In high-income countries, at least one-third of adults who have strokes caused by spontaneous (non-traumatic) intracerebral hemorrhage (ICH) have been taking oral antithrombotic therapy due to their comorbidities and other risk factors for vascular diseases ( Antiplatelet or anticoagulant) medications .

Vascular Thrombosis Myocardial Infarction

Antiplatelet drugs may benefit survivors of spontaneous ICH, but their impact on major vascular events is uncertain

RESTART included ICH survivors on antithrombotic therapy to estimate the impact of initiating and avoiding antiplatelet therapy on recurrent symptomatic ICH, and whether this risk may exceed any reduction in occlusive vascular events

After a median follow-up of 537 participants for 2 years, the main results of RESTART ruled out all risks, but there was a very small increase in the risk of recurrence of ICH after antiplatelet therapy (adjusted hazard ratio [HR] , 0.

prevention

Participants were followed for up to 7 years for primary outcomes (recurrent symptomatic ICH) and secondary outcomes (all major vascular events)

A total of 537 patients (median age, 76.

The main result of recurrent ICH affected 22 of the 268 participants (8.

Major vascular events affected 72 participants (26.

This study found that antiplatelet therapy had no statistically significant effect on recurrent ICH or all major vascular events

Original Source:

Effects of Antiplatelet Therapy After Stroke Caused by Intracerebral Hemorrhage: Extended Follow-up of the RESTART Randomized Clinical Trial.
JAMA

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