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JAMA Neurology-After 20 years of follow-up, it was found that the overall disability rate of children with multiple sclerosis gradually decreased

 Last Update: 2021-07-27
 Source: Internet
 Author: User

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The treatment of pediatric multiple sclerosis (POMS) is based on the use of disease-modifying therapies (DMTs) that have been tested in adults

Only fingolimod was tested in a randomized clinical trial (RCT) and showed that it is more effective in clinical and MRI results than interferon beta

manage

With this, Damiano Baroncini and others of the University of Bari Aldo Moro explored whether the course of POMS changes with changes in treatment and management standards

We explored whether the course of POMS changes with changes in treatment and management standards

A total of 3198 POMS patients were recruited (mean age at onset was 15.

The median survival time to reach EDSS scores of 4.

Over time, the cumulative risk of reaching disability milestones gradually decreased, both for EDSS scores of 4.

The significance of this study is that in POMS patients, the risk of persistent disability has been reduced by 50% to 70% in the most recent diagnosis, which may be due to improvements in treatment and management standards

In POMS patients, the risk of persistent disability has been reduced by 50% to 70% in the most recent diagnosis period.

JAMA

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