JAMA Neurology: A clinical study of Tau-PET protein imaging for prediction of Alzheimer's disease based on biomarkers

team introduction:

Corresponding author Professor Oskar Hansson is currently working in the Department of Forensic Biology at Lund University Hospital in Sweden and is also a visiting professor at the Mayo Clinic in the United States.

 From the official website of the Knut and Alice Wallenberg Foundation

Important knowledge points

Tau: It is a microtubule-associated protein, which is very abundant in neurons of the central nervous system and rare in other cells, and is also very low in astrocytes and oligodendrocytes in the central nervous system

AD: Alzheimer's disease

Aβ: β-amyloid

A/T/NBiomarkers: Biomarkers associated with beta-amyloid deposition/pathological tau/neurodegeneration

CU: Cognitive Impairment

MCI: Mild Cognitive Impairment

PET: Positron Emission Tomography

SUVR: Normalized Uptake Value Ratio

background

Longitudinal tau protein aggregation in the brain in different clinical stages of Alzheimer's disease (AD) is a research hotspot in the current field.

result

(1) Changes in participant characteristics and Tau PET

The characteristics of the participants are summarized in Table 1

Figure 1 Tau PET stage based on EBM division

Table 1.

(ii) Modeling changes in Tau PET using individual predictors

We analyzed the association of individual biomarkers with annual changes in [18F]RO948 tau PET SUVR (Table 2)

Figure 2.

Table 2.

(3) Efficacy analysis of theoretical clinical trials

We analyzed which biomarker combinations were most closely associated with annual increases in [18F]RO948 SUVR and concluded that in Aβ-positive CU individuals and Aβ-positive MCI individuals, combined plasma p-tau217 and baseline tau PET The model proved to be the best (Table 3)

Table 3.

In conclusion, we believe that the combination of plasma p-tau217 and tau PET is the best choice for predicting preclinical and prodromal stages of AD, and can reduce the sample size of clinical trials with tau PET as one of the primary outcomes

references

Leuzy A, Smith R, Cullen NC, et al.

Compilation author: Gao toutou (Brainnews creative team) 

Reviewer: Fat Rabbit Coco (Brainnews Editorial Office)

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