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JAMA Neuro: Spatial extent of Aβ levels and correlation with Tau-PET and cognition

 Last Update: 2022-09-06
 Source: Internet
 Author: User

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Prevention trials of anti-amyloid agents would ideally enroll those who first showed biologically relevant β-amyloid (Aβ) binding on positron emission tomography (PET)

This longitudinal multicenter cohort study included 3 independent cohorts: PREVENT-AD (data collected 2012-2020), ADNI (2005-2019), and HABS (2011-2019)

Results A total of 817 participants were included, including 129 from the PREVENT-AD cohort (mean [SD] age, 63.

Participants with extensive amyloid binding further exhibited significant cognitive decline (significant β = -0.

Taken together, regional Aβ binding appears to be biologically relevant, and participants at this stage remain relatively free of CSF phosphorylated tau181, tau-PET binding and associated cognitive decline, making them anti-amyloid agents ideal target

references:

Spatial Extent of Amyloid-β Levels and Associations With Tau-PET and Cognition.

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