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The number of babies born through assisted reproductive technology (ART) is gradually increasing worldwide, and in 2018, about 1 in 20 births in Taiwan were born with the help of ART (5.
The aim of this study was to determine the association between different modes of conception and childhood cancer, as well as the potential mediating role of preterm birth and low birth weight
This nationwide, population-based cohort study included registration data from 2,308,016 eligible parent-child triads in Taiwan from January 1, 2004 to December 31, 2017
Conception pattern, defined as (1) natural conception, (2) subfertility and non-ART (ie, infertility diagnosis but no ART-promoted conception), or (3) ART (eg, infertility diagnosis and ART-promoted conception), The primary outcome was a diagnosis of childhood cancer according to the International Classification of Childhood Cancer, third edition
The results of the study found that of the 2,308,016 children, 52.
Comparison of cancer risk in children conceived with ART, subfertility, and children conceived without ART
In conclusion, in this cohort study, children conceived through ART were at higher risk of cancer than children conceived naturally, and the increased risk could not be explained by preterm birth or low birth weight
references:
Weng S, Huang Y, Huang Y, Li Y, Chien L.
