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JAMA Net Open: Offspring with concurrent exposure to preeclampsia, perinatal complications, neurodevelopmental disorders, high risk of psychiatric disorders

 Last Update: 2022-04-23
 Source: Internet
 Author: User

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Preeclampsia is associated with an increased risk of several neurodevelopmental disorders in offspring, including autism spectrum disorder (ASD), attention deficit/hyperactivity disorder (ADHD), schizophrenia, intellectual disability, epilepsy, and cerebral palsy

Linghua Kong Linghua Kong et al.

This population-based cohort study used data from the Finnish National Registry to assess all singleton live births between 1 January 1996 and 31 December 2014 (N = 1012723)

Among 1 012 723 singleton live births (51.

Maternal preeclampsia and incidence of neurodevelopmental and psychiatric disorders in offspring

Compared with offspring not exposed to preeclampsia or not exposed to preeclampsia or perinatal complications, after adjustment for potential confounders (adjusted hazard ratio [aHR], 2.

After adjustment for potential confounders compared with offspring not exposed to preeclampsia or not exposed to preeclampsia or perinatal complications After adjusting for potential confounders (adjusted hazard ratio [aHR], 2.

Association of maternal preeclampsia and perinatal complications with risk of neurodevelopmental and psychiatric disorders in offspring

The sibling pair analysis did not find an increased risk of neurodevelopmental or psychiatric disorders after exposure to preeclampsia alone, but intellectual disability in offspring exposed to preeclampsia and perinatal complications (aHR, 3.

Sibling pair analysis did not find an increased risk of neurodevelopmental or psychiatric disorders after exposure to preeclampsia alone, but intellectual disability in offspring exposed to preeclampsia and perinatal complications did not find exposure to preeclampsia alone Increased risk of post-neurodevelopmental or psychiatric disorders but intellectual disability in offspring exposed to preeclampsia and perinatal complications (aHR, 3.

This cohort study found that offspring exposed to maternal preeclampsia and perinatal complications had a slightly increased risk of developing intellectual disability, specific developmental disorders, ADHD and conduct disorders, and other behavioral and emotional disorders

original source

Kong L, Chen X, Liang Y, Forsell Y, Gissler M, Lavebratt C.

Kong L, Chen X, Liang Y, Forsell Y, Gissler M, Lavebratt C.
Association of Preeclampsia and Perinatal Complications With Offspring Neurodevelopmental and Psychiatric Disorders.
JAMA Netw Open.
2022;5(1):e2145719.
doi:10.
1001/jamanetworkopen.
2021.
45719 Kong L, Chen X, Liang Y, Forsell Y, Gissler M, Lavebratt C.
Association of Preeclampsia and Perinatal Complications With Offspring Neurodevelopmental and Psychiatric Disorders.
JAMA Netw Open.

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