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JAMA Dermatol: Comparison of the efficacy of systemic immunomodulatory therapy for atopic dermatitis

 Last Update: 2022-04-23
 Source: Internet
 Author: User

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Systemic immunomodulators used to treat atopic dermatitis include cyclosporine, methotrexate, azathioprine, mycophenolate mofetil, and dupilumab, abrutinib, braziltinib, tralotinib Kinumab and upadacitinib were recently approved in different countries
.

There are few face-to-face trials of these drugs, making direct comparisons of efficacy and safety difficult

Since October 2019, 21 new studies have been added for a total of 60 trials with a total of 16 579 patients
.

Adults treated for up to 16 weeks, abrocitinib, 200 mg daily (mean difference [MD], 2.

Our study found that acrotinib 200 mg daily and upadacitinib 30 mg daily may have slightly higher index scores than dupilumab 600 mg and 300 mg biweekly
.

Our results may help clinicians understand the differences between different treatment options for moderate-to-severe atopic dermatitis

Source: Drucker AM, Morra DE, Prieto-Merino D, Systemic Immunomodulatory Treatments for Atopic Dermatitis: Update of a Living Systematic Review and Network Meta-analysis.

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