JAMA: Antihypertensive therapy can improve the risk of dementia and cognitive impairment in people with high blood pressure
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Last Update: 2020-05-29
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Source: Internet
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Author: User
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Researchers recently conducted a systematic review and meta-analysis to examine the relationship between lower blood pressure, dementia, or cognitive impairmentresearchers collected data as of December 31, 2019 to assess the effect slower blood pressure on cognitive outcomes, and the control group consisted of a placebo, an alternative antihypertensive drug, or a high blood pressure target drugThe main endpoints of the study were dementia or cognitive impairment, and the secondary endpoints were cognitive decline and changes in cognitive test scores14 studies, involving a total of 96,158 participants with an average age of 69 years, 42.2% of women, an average arterial pressure of 154 mmHg, diastomy pressure of 83.3 mmHg, follow-up 49.2 monthsCompared to the control group, the risk of dementia and cognitive impairment decreased after the use of antihypertensive drugs (4.1 year follow-up, 7.0% vs 7.5%, HR -0.93, absolute risk reduced by 0.39%), and reduced risk of cognitive decline (4.1 year follow-up, 20.2% vs 21.1%, HR 0.93, absolute risk decreased by 0.71%)Lowering blood pressure did not significantly alter the cognitive test scorestudies have found that antihypertensive therapy can improve the risk of dementia and cognitive impairment in people with high blood pressure
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