JAHA: Relationship between the N end of the brain and atrial sodium peptide preaphed and the dynamic brain auto-regulation.

Elevated sodium peptide (NP) is associated with adverse cerebrovascular diseases, including stroke, cerebrovascular disease and dementia.
, however, the mechanisms for these associations are not yet clear.
a recent study published in JAHA, an authoritative journal in the field of cardiovascular disease, in which researchers evaluated the relationship between the N-end of the cerebrosine peptide prebiotor (NT-proBNP) and the N-end of the atrial sodium peptide presage (NT-proANP) and cerebrovascular function.
researchers included 154 participants in the Young Coronary Arterial Risk Development (CARDIA) queue (with an average age of 56±4 years), who measured NT-proBNP and NT-proANP levels using electrochemical luminescent immunoassays and enzyme-linked immunoassays from blood samples taken during the 25th year of assessment, respectively.
Dynamic Brain Auto-Regulation (dCA) was determined in the 30th year of the assessment by a cranial Doppler ultrasound, and the researchers used a transfer function analysis (phase and gain) of spontaneous blood pressure and flow rate oscillations, where lower phases and higher gain reflected lower brain auto-regulation efficiency.
researchers used a multivariable linear regression model that adjusted demographics, vascular risk factors, and the history of kidney and heart disease.
25th year higher NT-proBNP levels are associated with lower phases (β-5.30), lower phase amplitudes (-10.05 to -0.54) and higher gain (β (95%CI) and 0.06 (0.004-0.12 cm/smHg).
, higher NT-proANP levels are associated with lower phases (β--9.08) and lower phase amplitudes (-16.46 to -1.70).
, it can be seen that higher NT-proBNP and NT-proANP levels are associated with lower dCA efficiency.
these results suggest a link between circulating NP and automatic brain regulation, possibly a mechanism for linking NP to poor cerebrovascular prognosmation.
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