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Phenytropines and morphine are given during acute coronary syndrome (ACS) to relieve anxiety and pain, and β blockers can also relieve pain.
ACS can induce post-traumatic stress disorder (PTSD) symptoms (PTSS).
taking benzodiazepines during trauma rather than acute coronary syndrome increases the risk of ACS, it is not clear whether benzodiazepines increase the risk of PTSS in ACS patients.
, researchers analyzed the effects of exposure to these drugs on the development of PTSS during ACS in a study published recently in JAHA, an authoritative journal for cardiovascular disease.
study participants, 154 confirmed ACS patients, obtained baseline demographics, clinical variables, and psychodetic indicators through medical history, psychodegnostic assessment, and patient records, and used them as covariables in linear regression analysis.
three months after using ACS, the researchers assessed the severity of PTSS in subjects using a clinician-administered PTSD scale.
During ACS, 37.7 percent of patients were exposed to benzodiazepines, while 72.1 percent were exposed to morphine and 88.3 percent were exposed to β blockers, but only 7.1 percent were exposed to antidepressants.
18 patients (11.7%) had clinical PTSD.
adjustment of all covariates, the use of benzodiazepines was significantly related to the overall severity score of the clinician-administered PTSD scale (non-standardized coefficient B (SE) was 0.589 (0.274);
the symptoms of acute stress disorder, the relative risk of clinical PTSD in patients exposed to benzodiazepines increased nearly fourfold (ratio ratio was 3.75; 95% confidence interval was 1.31-10.77).
morphine, β, and antidepressants had no predicted value.
, it can be seen that although benzodiazepines have short-term anti-anxiety effects during ACS, they may increase the risk of ACS-induced PTSS, which can affect the quality of life and prognostics of patients.