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Antiplate plate plate therapy increases the risk of hematoma expansion in patients with cerebral hemorrhage (ICH), and the effect on the patient's functional prognosis is not yet clear.
Recently, a research article was published in JAHA, an authoritative journal in the field of cardiovascular disease, which is an exploratory analysis of the trial of double-blind, randomized, placebo-controlled TICH-2 (treatment of cerebral hemorrhage patients with acetate, which analyzed the efficacy of treatment with methylacycline in patients with spontaneous ICH within 8 hours of onset).
researchers conducted multivariate logistic regression and sequential regression to explore the relationship between pre-ICH antiplatelet therapy and 24-hour hematoma enlargement and 90-day improved Rankin scale scores, as well as the effects of aminocyclic acid.
of the 2,325 patients, 611 (26.3%) received pre-ICH antiplateplate therapy.
were older than the non-antiplate plateplate group (average age was 75.7 vs. vs. 66.5 years), ischemic heart disease (25.4% vs. 2.7%), ischemic stroke (36.2% vs. 6.3%), indoor cerebral hemorrhage (40.2% vs. 27.5%) are more likely, baseline hematoma volume (28.1 vs. 22.6 mL) is greater.
significantly increased risk of pre-ICH plateroid therapy associated with hematoma enlargement (corrected ratio ratio of 1.28; 95% CI is 1.01-1.63), while improved Rankin Table scores indicate a shift to adverse outcomes (corrected OR is 1.58; 95% CI is 1.32-1.91) and a higher risk of death on the 90th day (corrected OR is 1.63; 95% CI is 1.25-2.11).
treatment reduced all ICH patients (corrected OR 0.76; 95% CI 0.62-0.93) and antiplatelet therapy subgroups (corrected OR is 0.. 61;95% CI is 0.41-0.91) Risk of hematoma enlargement, there is no significant interaction between pre-ICH antiplatelet and aminocyclic acid therapy (interaction P=0.248).
, antiplate plate plate treatment is independently associated with hematoma enlargement and adverse function prognosis.
whether or not antiplatelet drugs are used, acetate treatment can reduce hematoma enlargement.
