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JAHA: Analysis of the effect of colchicine treatment in patients with coronary artery disease

 Last Update: 2021-08-14
 Source: Internet
 Author: User

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Inflammation plays a key role in coronary artery disease (CAD)
.

The anti-inflammatory drug colchicine seems to reduce ischemic events in CAD patients

Recently, the heart blood vessels published a research article on the disease areas authoritative magazine JAHA, in order to assess the effectiveness of colchicine in patients with acute and chronic CAD, the researchers conducted this systematic review and meta-analysis
.

Heart blood vessels

The researchers searched MEDLINE, EMBASE, CochraneCENTRAL and conference abstracts from January 1975 to October 2020, and included randomized trials evaluating the efficacy of colchicine and placebo/standard therapy in CAD patients
.

The researchers combined the data using a random effects model

The main outcome of the analysis

Among the 3108 citations, the researchers included 13 randomized trials (n=13125)
.

Compared with placebo/standard therapy, CAD patients treated with colchicine reduced myocardial infarction (odds ratio [OR] 0.
64; 95% CI 0.
46-0.
90; P=0.
01; I2=41%) and stroke /transitivity The risk of ischemic attack (OR 0.

Myocardial infarction of stroke In CAD patients, colchicine can reduce the risk of myocardial infarction and stroke, but the incidence of gastrointestinal discomfort is higher, and it has no effect on all-cause mortality

Original source:

Thomas Kofler.

et al.
Colchicine in Patients With Coronary Artery Disease: A Systematic Review and Meta‐Analysis of Randomized Trials .
JAHA.
2021.

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