JAD: Not happy at a young age?

In recent years, there is a popular saying that young people are becoming more and more vulnerable, and many people even suspect that they are suffering from depression
.

It is true that many young people suffer from depression and depression, but it is not accurate to say that the post-90s generation is more likely to suffer from depression or have depression tendency

From the perspective of the entire environment, the prevalence of every mental illness is actually inseparable from the environment in which it is located
.

Compared with the past, the current incidence of depression in the entire society is actually showing an upward trend

Compared with the past, the current incidence of depression in the entire society is actually showing an upward trend

Depressive symptoms may increase the risk of dementia, and depressive symptoms may increase the risk of dementia.

In order to summarize the depressive symptom trajectory of adults in each life stage, and estimate its relationship with cognitive impairment and decline, experts from the University of California, San Francisco (UCSF) collected 4 prospective cohorts (20-89 years old) Research, summarize the relevant results and publish them in the Journal of Alzheimer's Disease
.

According to the Depression Scale-10 (CESD-10) of the Center for Epidemiology Research, researchers measured 6122 elderly participants in early adulthood (20-49 years), middle (50-69 years), and late adulthood (70-89).
Years) time-weighted average was estimated
.

The adjusted collective logic and mixed-effects model estimated the relationship between the inductive depressive symptoms and two cognitive outcomes: cognitive impairment defined by established standards and comprehensive cognitive scores

The results showed that in a separate model, the increase in depressive symptoms at each life stage was associated with cognitive outcomes: the risk of cognitive impairment in early adulthood increased by 59% (20-49 years old, OR=1.
59, 95% CI: 1.
35, 1.
87 ); Intermediate increase of 94% (50-60 years old, OR=1.
94, 95%CI: 1.
16, 3.
26); and late 77% (70-89 years old OR=1.
77, 95%CI: 1.
42, 2.
21)
.

In a separate model, increased depressive symptoms at each life stage are associated with cognitive outcomes: the risk of cognitive impairment in early adulthood is increased by 59% (20-49 years old, OR=1.
59, 95% CI: 1.
35, 1.
87); mid-term An increase of 94% (50-60 years old, OR=1.
94, 95%CI: 1.
16, 3.
26); and 77% late (70-89 years old OR=1.
77, 95%CI: 1.
42, 2.
21)
.

In a separate model, increased depressive symptoms at each life stage are associated with cognitive outcomes: the risk of cognitive impairment in early adulthood is increased by 59% (20-49 years old, OR=1.

When the depressive symptoms in other life stages are adjusted, the increase in depressive symptoms in early adulthood (OR=1.
73; 95%CI: 1.
42, 2.
11) and later years (OR=1.
43; 95%CI: 1.
08, 1.
89) is still consistent with the recognition The 73% increase in the risk of cognitive impairment is related to 43%, and is also related to the speed of cognitive decline (P<0.
05)
.

When the depressive symptoms in other life stages are adjusted, the increase in depressive symptoms in early adulthood (OR=1.
73; 95%CI: 1.
42, 2.
11) and later years (OR=1.
43; 95%CI: 1.
08, 1.
89) is still consistent with the recognition The 73% increase in the risk of cognitive impairment is related to 43%, and is also related to the speed of cognitive decline (P<0.
05)
.

When the depressive symptoms in other life stages are adjusted, the increase in depressive symptoms in early adulthood (OR=1.

In summary, the study shows that early adulthood depressive symptoms may be a risk factor for cognitive impairment independent of depressive symptoms in middle or old age

references:

Depressive Symptoms Imputed Across the Life Course Are Associated with Cognitive Impairment and Cognitive Decline.

Depressive Symptoms Imputed Across the Life Course Are Associated with Cognitive Impairment and Cognitive Decline.
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